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- W4313385436 abstract "Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite. The parasite evades clearance by the immune system and instead persists in an encysted state within the brain parenchyma. The unique environment of the brain requires a tightly regulated immune response in which T cells are essential. Nonetheless, the mechanistic details of the chronic T cell response to the parasite remain incomplete. Flow cytometry analysis reveals phenotypic diversity among brain infiltrating T cells. CD8+ CD103+ T cells form a notable proportion of this group, comprising nearly 40% of the CD8+ T cell population at the late chronic stage. Expression of CD103 can define a tissue resident memory T cell (Trm). Whether Trm could play a role in control of a chronic infection has not yet been defined. Using flow cytometry and in situ immunostaining, we show that this population is specific to the parasite and can be found throughout the infected brain including the E-cadherin positive regions of the choroid plexus, the perivascular space, and within the parenchyma in proximity to the parasite cyst. Furthermore, using RNAseq analysis, we present preliminary data establishing that this population exhibits a unique transcriptional profile relative to other CD8+ T cells in the brain and periphery. This data suggests that CD8+ CD103+ T cells in the brain are indeed a functionally distinct population, laying the groundwork for further analysis." @default.
- W4313385436 created "2023-01-06" @default.
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- W4313385436 date "2016-05-01" @default.
- W4313385436 modified "2023-09-23" @default.
- W4313385436 title "Profiling CD8+ CD103+ T cells in the <i>Toxoplasma gondii</i> infected brain" @default.
- W4313385436 doi "https://doi.org/10.4049/jimmunol.196.supp.205.5" @default.
- W4313385436 hasPublicationYear "2016" @default.
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