Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385458> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313385458 endingPage "136.8" @default.
- W4313385458 startingPage "136.8" @default.
- W4313385458 abstract "Abstract We previously demonstrated that oral immunization with a murinized Listeria monocytogenes induced rapid formation of intestinal resident memory CD8 T (TRM) cells that were capable of providing secondary protection. It is well appreciated that systemic vaccination also induces a population of protective TRM cells in the intestine. We sought to understand the impact of immunization route on the development of intestinal TRM cells and protective immunity. Oral immunization resulted in significantly more antigen-specific effector CD8 T cells in the intestinal compartments than intravenous (i.v.) immunization, likely due to differential imprinting and migration of T cells. While both oral and i.v. immunization induced a4b7 expression on CD8 T cells, only oral immunization resulted in CCR9 expression. Moreover, compared to i.v.-induced CD8 T cells, oral-induced cells rapidly adopted a CD127+ KLRG-1− memory precursor phenotype and a CD103+ CD69+ residency phenotype. Furthermore, oral immunization led to a substantially larger TRM population in the intestine compared to i.v. immunization. While the majority of oral-induced TRM cells were CD103+, a substantial proportion of i.v.-induced TRM cells did not express CD103. Collectively, these data suggest that oral immunization would provide an optimal sentinel population of memory cells that are more efficient in providing protection against secondary intestinal exposure. Indeed, oral-immunized mice had reduced bacterial burden after challenge infection compared to i.v.-immunized mice. In conclusion, our studies demonstrate that route of immunization greatly affects the induction and maintenance of TRM cells and thus the outcome of immunization." @default.
- W4313385458 created "2023-01-06" @default.
- W4313385458 creator A5010514395 @default.
- W4313385458 creator A5080797961 @default.
- W4313385458 date "2016-05-01" @default.
- W4313385458 modified "2023-09-27" @default.
- W4313385458 title "Route of immunization governs the development of distinct resident memory CD8 T cells and protective immunity in the intestinal mucosa" @default.
- W4313385458 doi "https://doi.org/10.4049/jimmunol.196.supp.136.8" @default.
- W4313385458 hasPublicationYear "2016" @default.
- W4313385458 type Work @default.
- W4313385458 citedByCount "0" @default.
- W4313385458 crossrefType "journal-article" @default.
- W4313385458 hasAuthorship W4313385458A5010514395 @default.
- W4313385458 hasAuthorship W4313385458A5080797961 @default.
- W4313385458 hasConcept C147483822 @default.
- W4313385458 hasConcept C154317977 @default.
- W4313385458 hasConcept C167672396 @default.
- W4313385458 hasConcept C202751555 @default.
- W4313385458 hasConcept C203014093 @default.
- W4313385458 hasConcept C2779341262 @default.
- W4313385458 hasConcept C2780801004 @default.
- W4313385458 hasConcept C2908647359 @default.
- W4313385458 hasConcept C55493867 @default.
- W4313385458 hasConcept C71924100 @default.
- W4313385458 hasConcept C86803240 @default.
- W4313385458 hasConcept C8891405 @default.
- W4313385458 hasConcept C99454951 @default.
- W4313385458 hasConceptScore W4313385458C147483822 @default.
- W4313385458 hasConceptScore W4313385458C154317977 @default.
- W4313385458 hasConceptScore W4313385458C167672396 @default.
- W4313385458 hasConceptScore W4313385458C202751555 @default.
- W4313385458 hasConceptScore W4313385458C203014093 @default.
- W4313385458 hasConceptScore W4313385458C2779341262 @default.
- W4313385458 hasConceptScore W4313385458C2780801004 @default.
- W4313385458 hasConceptScore W4313385458C2908647359 @default.
- W4313385458 hasConceptScore W4313385458C55493867 @default.
- W4313385458 hasConceptScore W4313385458C71924100 @default.
- W4313385458 hasConceptScore W4313385458C86803240 @default.
- W4313385458 hasConceptScore W4313385458C8891405 @default.
- W4313385458 hasConceptScore W4313385458C99454951 @default.
- W4313385458 hasIssue "1_Supplement" @default.
- W4313385458 hasLocation W43133854581 @default.
- W4313385458 hasOpenAccess W4313385458 @default.
- W4313385458 hasPrimaryLocation W43133854581 @default.
- W4313385458 hasRelatedWork W1891584141 @default.
- W4313385458 hasRelatedWork W2001055320 @default.
- W4313385458 hasRelatedWork W2008949385 @default.
- W4313385458 hasRelatedWork W2057948995 @default.
- W4313385458 hasRelatedWork W2111460888 @default.
- W4313385458 hasRelatedWork W2220102944 @default.
- W4313385458 hasRelatedWork W2391198628 @default.
- W4313385458 hasRelatedWork W2409441623 @default.
- W4313385458 hasRelatedWork W2903752946 @default.
- W4313385458 hasRelatedWork W3032210197 @default.
- W4313385458 hasVolume "196" @default.
- W4313385458 isParatext "false" @default.
- W4313385458 isRetracted "false" @default.
- W4313385458 workType "article" @default.