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- W4313385461 abstract "Abstract Diferuloylmethane (cucurmin), a natural phenol chemical isolated from the plant Curcuma longa (turmeric, is thought to be anti-inflammatory, and has been shown to ameliorate autoimmune diseases, i.e., multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease. We examined the effects of diferuloylmethane on type I diabetes development and the immune response in NOD mice. Treatment of NOD dendritic cells (DC) with diferuloylmethane decreased pro-inflammatory cytokines (e.g., IL-12) in vitro, but had no effect on the anti-inflammatory cytokine, IL-10, or DC viability. Interestingly, the ability of diferuloylmethane-treated NOD DC to induce IFNγ-producing T cells in vitro was decreased by comparison to controls. In in vivo studies, NOD mice treated with diferuloylmethane three times weekly exhibited significantly delayed disease (type 1 diabetes) onset, and dramatically decreased disease incidence and increased survival. This protection was associated with a significant decrease in IFNγ production by T cells in the spleen and pancreatic LN. Moreover, the frequencies of CD4+Foxp3+ and CD4+Foxp3+Neuropilin− cells in the pancreatic LN were not increased by this treatment. Overall, our in vitro and in vivo data show that diferuloylmethane suppresses the differentiation of the IFNγ-producing cells that are involved in type 1 diabetes development. Diferuloylmethane may, therefore, have therapeutic potential for the prevention of the development of type 1 diabetes. Experiments are ongoing to test a more effective delivery system that could enhance bioavailability, i.e., diferuloylmethane-encapsulated nanoparticles." @default.
- W4313385461 created "2023-01-06" @default.
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- W4313385461 date "2016-05-01" @default.
- W4313385461 modified "2023-09-27" @default.
- W4313385461 title "Diferuloylmethane prevents type 1 diabetes development via inhibition of IFNγ-producing T cells." @default.
- W4313385461 doi "https://doi.org/10.4049/jimmunol.196.supp.70.11" @default.
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