Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385483> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313385483 endingPage "74.1" @default.
- W4313385483 startingPage "74.1" @default.
- W4313385483 abstract "Abstract Regulatory T cells (Tregs) are critical mediators of tumor immune suppression. While Tregs are found in established tumors, little is known about the kinetics and dynamics of Treg accumulation and the factors promoting it during oncogene-driven tumorigenesis. The present studies characterize Treg response kinetics and conversion dynamics during early tumor development in a model of autochthonous, tamoxifen-inducible BrafV600E Pten−/− melanoma. While microscopic skin dysplasia appeared 16 days following tumor induction, FoxP3+ Treg frequency and absolute numbers accumulated by day 26, coinciding with locally-invasive neoplasm development. BrafV600E inhibition with PLX4720 prevented Treg accumulation, suggesting that oncogenic Braf controls this process. Following adoptive transfer of CD4+ T cells specific to TRP-1, antigen-specific FoxP3+ Tregs preferentially accumulated in tumor-induced skin and draining lymph nodes (dLNs), as compared to tumor-free counterparts. In contrast, depleting Tregs prior to transfer abrogated the TRP-1-specific Treg response, suggesting a predominant role for natural Tregs. Furthermore, we observed an increase in chemokine (C-C motif) ligand 17 (Ccl17) and Ccl2 prior to Treg influx to tumor-induced skin. Oncogenic Braf regulated expression of Ccl17 and Ccl2, both of which mediated Treg migration in vitro. We are currently investigating the putative role of Ccl17/2-Ccr4 chemotactic axis in Treg recruitment to sites of Braf-driven tumorigenesis in vivo." @default.
- W4313385483 created "2023-01-06" @default.
- W4313385483 creator A5010282179 @default.
- W4313385483 creator A5010958654 @default.
- W4313385483 creator A5058797896 @default.
- W4313385483 creator A5089219799 @default.
- W4313385483 date "2016-05-01" @default.
- W4313385483 modified "2023-09-27" @default.
- W4313385483 title "Elucidating the oncogene-driven regulatory T cell responses during melanoma tumorigenesis." @default.
- W4313385483 doi "https://doi.org/10.4049/jimmunol.196.supp.74.1" @default.
- W4313385483 hasPublicationYear "2016" @default.
- W4313385483 type Work @default.
- W4313385483 citedByCount "0" @default.
- W4313385483 crossrefType "journal-article" @default.
- W4313385483 hasAuthorship W4313385483A5010282179 @default.
- W4313385483 hasAuthorship W4313385483A5010958654 @default.
- W4313385483 hasAuthorship W4313385483A5058797896 @default.
- W4313385483 hasAuthorship W4313385483A5089219799 @default.
- W4313385483 hasConcept C121608353 @default.
- W4313385483 hasConcept C12823836 @default.
- W4313385483 hasConcept C13373296 @default.
- W4313385483 hasConcept C143172330 @default.
- W4313385483 hasConcept C203014093 @default.
- W4313385483 hasConcept C2776090121 @default.
- W4313385483 hasConcept C2777658100 @default.
- W4313385483 hasConcept C2778296632 @default.
- W4313385483 hasConcept C2779727006 @default.
- W4313385483 hasConcept C502942594 @default.
- W4313385483 hasConcept C54355233 @default.
- W4313385483 hasConcept C555283112 @default.
- W4313385483 hasConcept C79484868 @default.
- W4313385483 hasConcept C86803240 @default.
- W4313385483 hasConcept C8891405 @default.
- W4313385483 hasConcept C90375314 @default.
- W4313385483 hasConceptScore W4313385483C121608353 @default.
- W4313385483 hasConceptScore W4313385483C12823836 @default.
- W4313385483 hasConceptScore W4313385483C13373296 @default.
- W4313385483 hasConceptScore W4313385483C143172330 @default.
- W4313385483 hasConceptScore W4313385483C203014093 @default.
- W4313385483 hasConceptScore W4313385483C2776090121 @default.
- W4313385483 hasConceptScore W4313385483C2777658100 @default.
- W4313385483 hasConceptScore W4313385483C2778296632 @default.
- W4313385483 hasConceptScore W4313385483C2779727006 @default.
- W4313385483 hasConceptScore W4313385483C502942594 @default.
- W4313385483 hasConceptScore W4313385483C54355233 @default.
- W4313385483 hasConceptScore W4313385483C555283112 @default.
- W4313385483 hasConceptScore W4313385483C79484868 @default.
- W4313385483 hasConceptScore W4313385483C86803240 @default.
- W4313385483 hasConceptScore W4313385483C8891405 @default.
- W4313385483 hasConceptScore W4313385483C90375314 @default.
- W4313385483 hasIssue "1_Supplement" @default.
- W4313385483 hasLocation W43133854831 @default.
- W4313385483 hasOpenAccess W4313385483 @default.
- W4313385483 hasPrimaryLocation W43133854831 @default.
- W4313385483 hasRelatedWork W130785812 @default.
- W4313385483 hasRelatedWork W1535737655 @default.
- W4313385483 hasRelatedWork W1978189790 @default.
- W4313385483 hasRelatedWork W2019705985 @default.
- W4313385483 hasRelatedWork W2078792455 @default.
- W4313385483 hasRelatedWork W2081004502 @default.
- W4313385483 hasRelatedWork W2163016818 @default.
- W4313385483 hasRelatedWork W3028563194 @default.
- W4313385483 hasRelatedWork W3092937783 @default.
- W4313385483 hasRelatedWork W94147574 @default.
- W4313385483 hasVolume "196" @default.
- W4313385483 isParatext "false" @default.
- W4313385483 isRetracted "false" @default.
- W4313385483 workType "article" @default.