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- W4313385495 abstract "Abstract LIGHT is a member of the TNF superfamily, which is known to be involved in liver pathologies. Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses. The polyinosine-polycytidylic acid (Poly(I:C), a TLR3 viral mimetic, induces an acute hepatic injury and mimics a model of viral hepatitis. In this study, we investigated the role of LIGHT in acute hepatitis induced by poly(I:C). The results show that administration of poly(I:C)/D-galactosamine (D-GalN) in mice led to acute liver injury associated with the increased expression of LIGHT in liver. Blockade of LIGHT/HVEM signaling ameliorated liver injury. Pre-treatment with a NF-κB inhibitor dramatically reduced LIGHT expression and liver injury, suggesting the involvement of NF-κB in LIGHT expression in poly(I:C)/D-GalN-induced acute hepatitis." @default.
- W4313385495 created "2023-01-06" @default.
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- W4313385495 date "2016-05-01" @default.
- W4313385495 modified "2023-10-14" @default.
- W4313385495 title "Critical role of LIGHT/TNFSF14 in poly(I:C)-induced acute hepatitis" @default.
- W4313385495 doi "https://doi.org/10.4049/jimmunol.196.supp.124.48" @default.
- W4313385495 hasPublicationYear "2016" @default.
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