Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385535> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313385535 endingPage "119.7" @default.
- W4313385535 startingPage "119.7" @default.
- W4313385535 abstract "Abstract Intercellular adhesion molecule-1 (ICAM-1) is one of important molecules involved in neutrophil recruitment and works as a ligand for integrin leukocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) on neutrophils. Full-length ICAM-1 consists of five domains (D1–D2–D3–D4–D5) and D1 is a ligand binding domain for LFA-1 and D3 is for Mac-1. In addition, several alternative splicing variants exist as shown in transgenic mice. ICAM-1 Exon 4 deletion mice express D1D4D5, D1D2D5 and D1D5, while exon 5 deletion mice express D1D2D3D5, D1D2D5 and D1D5. The previous report of sepsis model showed exon 4 deletion mice showed significant reduction in neutrophil recruitment to liver with no mortality, while almost all of exon 5 deletion mice died with a large neutrophil recruitment. The mortality of WT mice was better than that of exon 5 deletion mice and worse than that of exon 4 deletion mice. These results suggest that ICAM-1 isoforms have functional roles in neutrophil recruitment. Our sepsis model demonstrated that neutrophil recruitment to liver was not affected in LFA-1 knockout mice and was reduced significantly in Mac-1 knockout mice. We speculated that ICAM-1 isoforms have functional roles via the interaction with Mac-1. Our PCR experiments demonstrated that liver highly expressed full length ICAM-1, D1D3D4D5 and D1D2D3D5 with full length ICAM-1 at the most abundant amount. Both D1D3D4D5 and D1D2D3D5 contain D3 and potentially bind to Mac-1. We expressed D1D3D4D5 and D1D2D3D5 along with full-length ICAM-1 in 293T cells, and examined the binding to Mac-1. Our preliminary data suggest that D1D2D3D5 bound more strongly to Mac-1 than full-length, supporting our hypothesis." @default.
- W4313385535 created "2023-01-06" @default.
- W4313385535 creator A5015363564 @default.
- W4313385535 date "2016-05-01" @default.
- W4313385535 modified "2023-09-25" @default.
- W4313385535 title "The role of ICAM-1 isoforms in neutrophil recruitment to liver" @default.
- W4313385535 doi "https://doi.org/10.4049/jimmunol.196.supp.119.7" @default.
- W4313385535 hasPublicationYear "2016" @default.
- W4313385535 type Work @default.
- W4313385535 citedByCount "0" @default.
- W4313385535 crossrefType "journal-article" @default.
- W4313385535 hasAuthorship W4313385535A5015363564 @default.
- W4313385535 hasConcept C104317684 @default.
- W4313385535 hasConcept C153911025 @default.
- W4313385535 hasConcept C16224149 @default.
- W4313385535 hasConcept C182704531 @default.
- W4313385535 hasConcept C185946421 @default.
- W4313385535 hasConcept C194583182 @default.
- W4313385535 hasConcept C203014093 @default.
- W4313385535 hasConcept C2776914184 @default.
- W4313385535 hasConcept C2778384902 @default.
- W4313385535 hasConcept C2778593620 @default.
- W4313385535 hasConcept C2909375385 @default.
- W4313385535 hasConcept C36823959 @default.
- W4313385535 hasConcept C53345823 @default.
- W4313385535 hasConcept C54355233 @default.
- W4313385535 hasConcept C77957584 @default.
- W4313385535 hasConcept C86803240 @default.
- W4313385535 hasConcept C95444343 @default.
- W4313385535 hasConceptScore W4313385535C104317684 @default.
- W4313385535 hasConceptScore W4313385535C153911025 @default.
- W4313385535 hasConceptScore W4313385535C16224149 @default.
- W4313385535 hasConceptScore W4313385535C182704531 @default.
- W4313385535 hasConceptScore W4313385535C185946421 @default.
- W4313385535 hasConceptScore W4313385535C194583182 @default.
- W4313385535 hasConceptScore W4313385535C203014093 @default.
- W4313385535 hasConceptScore W4313385535C2776914184 @default.
- W4313385535 hasConceptScore W4313385535C2778384902 @default.
- W4313385535 hasConceptScore W4313385535C2778593620 @default.
- W4313385535 hasConceptScore W4313385535C2909375385 @default.
- W4313385535 hasConceptScore W4313385535C36823959 @default.
- W4313385535 hasConceptScore W4313385535C53345823 @default.
- W4313385535 hasConceptScore W4313385535C54355233 @default.
- W4313385535 hasConceptScore W4313385535C77957584 @default.
- W4313385535 hasConceptScore W4313385535C86803240 @default.
- W4313385535 hasConceptScore W4313385535C95444343 @default.
- W4313385535 hasIssue "1_Supplement" @default.
- W4313385535 hasLocation W43133855351 @default.
- W4313385535 hasOpenAccess W4313385535 @default.
- W4313385535 hasPrimaryLocation W43133855351 @default.
- W4313385535 hasRelatedWork W1990555879 @default.
- W4313385535 hasRelatedWork W2010473138 @default.
- W4313385535 hasRelatedWork W2042535624 @default.
- W4313385535 hasRelatedWork W2052490065 @default.
- W4313385535 hasRelatedWork W2109583711 @default.
- W4313385535 hasRelatedWork W2311666036 @default.
- W4313385535 hasRelatedWork W2490665538 @default.
- W4313385535 hasRelatedWork W3172369665 @default.
- W4313385535 hasRelatedWork W4313385535 @default.
- W4313385535 hasRelatedWork W97713655 @default.
- W4313385535 hasVolume "196" @default.
- W4313385535 isParatext "false" @default.
- W4313385535 isRetracted "false" @default.
- W4313385535 workType "article" @default.