Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385587> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313385587 endingPage "207.14" @default.
- W4313385587 startingPage "207.14" @default.
- W4313385587 abstract "Abstract HIV infection is characterized by high-level replication in gut-associated lymphoid tissues (GALT). This occurs in part because α4β7 +/CD4+ T cells are a preferred target of HIV infection. α4β7 functions as a gut homing receptor. Homing is mediated through a specific interaction with MAdCAM that is expressed on the surface of the high-endothelial venules that line the gut. In addition, α4β7 binds to the V2 domain of HIV gp120. In an SIV model of HIV mucosal transmission, an antibody specific for α4β7 +was found to prevent infection, but the underlying mechanism for this protection is not fully understood. We have proposed that signaling through α4β7 + facilitates HIV transmission, and that the protection from infection that we observed may reflect the capacity of the anti-α4β7 mAb we employed to interfere with this signaling. In order to investigate the role of α4β7+ signaling in mucosal transmission, we have employed a newly developed adhesion assay (Peachman and Rao) that measures the interaction between either the V2 domain of HIV gp120 or MAdCAM with cells expressing α4β7. We have used this assay to evaluate small molecules and antibody antagonists of these interactions. We have found that small molecule antagonists that bind to the active site in α4β7 abrogate binding of cells to both MAdCAM and the V2 domain of HIV gp120. In addition, we determined that retinoic acid increases the adhesion of MAdCAM and V2 to α4β7 expressing cells. This assay should aid in the development of novel strategies designed to interfere with the trafficking of α4β7 +cells to GALT and to mucosal transmission of HIV." @default.
- W4313385587 created "2023-01-06" @default.
- W4313385587 creator A5029361786 @default.
- W4313385587 creator A5031736334 @default.
- W4313385587 creator A5033386202 @default.
- W4313385587 creator A5037396810 @default.
- W4313385587 creator A5041092935 @default.
- W4313385587 creator A5069927787 @default.
- W4313385587 creator A5087451794 @default.
- W4313385587 date "2016-05-01" @default.
- W4313385587 modified "2023-09-27" @default.
- W4313385587 title "Evaluation of a newly developed assay designed to assess the interaction between α4β7 and MAdCAM" @default.
- W4313385587 doi "https://doi.org/10.4049/jimmunol.196.supp.207.14" @default.
- W4313385587 hasPublicationYear "2016" @default.
- W4313385587 type Work @default.
- W4313385587 citedByCount "0" @default.
- W4313385587 crossrefType "journal-article" @default.
- W4313385587 hasAuthorship W4313385587A5029361786 @default.
- W4313385587 hasAuthorship W4313385587A5031736334 @default.
- W4313385587 hasAuthorship W4313385587A5033386202 @default.
- W4313385587 hasAuthorship W4313385587A5037396810 @default.
- W4313385587 hasAuthorship W4313385587A5041092935 @default.
- W4313385587 hasAuthorship W4313385587A5069927787 @default.
- W4313385587 hasAuthorship W4313385587A5087451794 @default.
- W4313385587 hasConcept C151872237 @default.
- W4313385587 hasConcept C159047783 @default.
- W4313385587 hasConcept C159654299 @default.
- W4313385587 hasConcept C16224149 @default.
- W4313385587 hasConcept C170493617 @default.
- W4313385587 hasConcept C18903297 @default.
- W4313385587 hasConcept C195687474 @default.
- W4313385587 hasConcept C203014093 @default.
- W4313385587 hasConcept C2781121885 @default.
- W4313385587 hasConcept C4175445 @default.
- W4313385587 hasConcept C542903549 @default.
- W4313385587 hasConcept C54355233 @default.
- W4313385587 hasConcept C55493867 @default.
- W4313385587 hasConcept C81885089 @default.
- W4313385587 hasConcept C86803240 @default.
- W4313385587 hasConcept C95444343 @default.
- W4313385587 hasConceptScore W4313385587C151872237 @default.
- W4313385587 hasConceptScore W4313385587C159047783 @default.
- W4313385587 hasConceptScore W4313385587C159654299 @default.
- W4313385587 hasConceptScore W4313385587C16224149 @default.
- W4313385587 hasConceptScore W4313385587C170493617 @default.
- W4313385587 hasConceptScore W4313385587C18903297 @default.
- W4313385587 hasConceptScore W4313385587C195687474 @default.
- W4313385587 hasConceptScore W4313385587C203014093 @default.
- W4313385587 hasConceptScore W4313385587C2781121885 @default.
- W4313385587 hasConceptScore W4313385587C4175445 @default.
- W4313385587 hasConceptScore W4313385587C542903549 @default.
- W4313385587 hasConceptScore W4313385587C54355233 @default.
- W4313385587 hasConceptScore W4313385587C55493867 @default.
- W4313385587 hasConceptScore W4313385587C81885089 @default.
- W4313385587 hasConceptScore W4313385587C86803240 @default.
- W4313385587 hasConceptScore W4313385587C95444343 @default.
- W4313385587 hasIssue "1_Supplement" @default.
- W4313385587 hasLocation W43133855871 @default.
- W4313385587 hasOpenAccess W4313385587 @default.
- W4313385587 hasPrimaryLocation W43133855871 @default.
- W4313385587 hasRelatedWork W1843298502 @default.
- W4313385587 hasRelatedWork W1981361863 @default.
- W4313385587 hasRelatedWork W2038043114 @default.
- W4313385587 hasRelatedWork W2070226647 @default.
- W4313385587 hasRelatedWork W2083879052 @default.
- W4313385587 hasRelatedWork W2130435458 @default.
- W4313385587 hasRelatedWork W2361629369 @default.
- W4313385587 hasRelatedWork W2606096564 @default.
- W4313385587 hasRelatedWork W2729974503 @default.
- W4313385587 hasRelatedWork W3001741696 @default.
- W4313385587 hasVolume "196" @default.
- W4313385587 isParatext "false" @default.
- W4313385587 isRetracted "false" @default.
- W4313385587 workType "article" @default.