Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385604> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313385604 endingPage "62.6" @default.
- W4313385604 startingPage "62.6" @default.
- W4313385604 abstract "Abstract Recognition of pathogens by the cell is paramount for the initiation of an appropriate immune response. A subset of pattern-recognition receptor family, including NLRP3, NLRC4 and AIM2, are cytosolic sensors which induce formation of the inflammasome, a multi-protein complex which drives the release of the pro-inflammatory cytokines IL-1β and IL-18. Here, we found that guanylate-binding proteins and other novel interferon-inducible GTPases were required for activation of the DNA-sensing AIM2 inflammasome during infection with Francisella novicida. These proteins were recruited to the cell membrane of the bacteria to mediate bacteriolysis, and thereby, liberating DNA for sensing by AIM2. However, engagement of the AIM2 inflammasome by mouse cytomegalovirus or transfected double-stranded DNA did not require interferon-inducible GTPases. Our results reveal a specific mechanistic link between cell-autonomous immunity and innate immune sensing pathways in response to bacterial infection." @default.
- W4313385604 created "2023-01-06" @default.
- W4313385604 creator A5029791472 @default.
- W4313385604 creator A5047291224 @default.
- W4313385604 creator A5074251335 @default.
- W4313385604 date "2016-05-01" @default.
- W4313385604 modified "2023-09-27" @default.
- W4313385604 title "Guanylate-binding proteins and other interferon-inducible proteins are essential for the activation of the inflammasomes" @default.
- W4313385604 doi "https://doi.org/10.4049/jimmunol.196.supp.62.6" @default.
- W4313385604 hasPublicationYear "2016" @default.
- W4313385604 type Work @default.
- W4313385604 citedByCount "0" @default.
- W4313385604 crossrefType "journal-article" @default.
- W4313385604 hasAuthorship W4313385604A5029791472 @default.
- W4313385604 hasAuthorship W4313385604A5047291224 @default.
- W4313385604 hasAuthorship W4313385604A5074251335 @default.
- W4313385604 hasConcept C111289621 @default.
- W4313385604 hasConcept C136449434 @default.
- W4313385604 hasConcept C139964883 @default.
- W4313385604 hasConcept C170493617 @default.
- W4313385604 hasConcept C183786373 @default.
- W4313385604 hasConcept C187831198 @default.
- W4313385604 hasConcept C203014093 @default.
- W4313385604 hasConcept C207332259 @default.
- W4313385604 hasConcept C2776178377 @default.
- W4313385604 hasConcept C2777209026 @default.
- W4313385604 hasConcept C55493867 @default.
- W4313385604 hasConcept C56432331 @default.
- W4313385604 hasConcept C62478195 @default.
- W4313385604 hasConcept C86803240 @default.
- W4313385604 hasConcept C8891405 @default.
- W4313385604 hasConcept C95444343 @default.
- W4313385604 hasConceptScore W4313385604C111289621 @default.
- W4313385604 hasConceptScore W4313385604C136449434 @default.
- W4313385604 hasConceptScore W4313385604C139964883 @default.
- W4313385604 hasConceptScore W4313385604C170493617 @default.
- W4313385604 hasConceptScore W4313385604C183786373 @default.
- W4313385604 hasConceptScore W4313385604C187831198 @default.
- W4313385604 hasConceptScore W4313385604C203014093 @default.
- W4313385604 hasConceptScore W4313385604C207332259 @default.
- W4313385604 hasConceptScore W4313385604C2776178377 @default.
- W4313385604 hasConceptScore W4313385604C2777209026 @default.
- W4313385604 hasConceptScore W4313385604C55493867 @default.
- W4313385604 hasConceptScore W4313385604C56432331 @default.
- W4313385604 hasConceptScore W4313385604C62478195 @default.
- W4313385604 hasConceptScore W4313385604C86803240 @default.
- W4313385604 hasConceptScore W4313385604C8891405 @default.
- W4313385604 hasConceptScore W4313385604C95444343 @default.
- W4313385604 hasIssue "1_Supplement" @default.
- W4313385604 hasLocation W43133856041 @default.
- W4313385604 hasOpenAccess W4313385604 @default.
- W4313385604 hasPrimaryLocation W43133856041 @default.
- W4313385604 hasRelatedWork W1916325998 @default.
- W4313385604 hasRelatedWork W1997565497 @default.
- W4313385604 hasRelatedWork W2052395914 @default.
- W4313385604 hasRelatedWork W2352691678 @default.
- W4313385604 hasRelatedWork W2569288689 @default.
- W4313385604 hasRelatedWork W2724425486 @default.
- W4313385604 hasRelatedWork W2741813146 @default.
- W4313385604 hasRelatedWork W3124111517 @default.
- W4313385604 hasRelatedWork W4313368936 @default.
- W4313385604 hasRelatedWork W4313385604 @default.
- W4313385604 hasVolume "196" @default.
- W4313385604 isParatext "false" @default.
- W4313385604 isRetracted "false" @default.
- W4313385604 workType "article" @default.