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- W4313385608 abstract "Abstract Chlamydia trachomatis (CT), a bacterial pathogen responsible for sexually transmitted infections worldwide, causes severe inflammation including but not limited to, pelvic inflammatory disease, ectopic pregnancy and infertility in women. Secretion of inflammatory mediators plays a pivotal role in its pathogenesis of disease. Our laboratory published that IL-10 can down-regulate the secretion of inflammatory cytokines triggered by CT in mouse macrophages. Our goal in this study is to decipher the mechanisms of IL-10 down-regulation of CT-induced cytokines by focusing on the intracellular negative regulatory mediators, suppressor of cytokine signaling (SOCS) 1 and 3. We show that live CT and its recombinant major outer membrane protein (rMOMP), in a dose-dependent fashion, markedly induced the transcriptional upregulation of SOCS 1 and 3 in macrophages. In the presence of exogenously added recombinant IL-10, SOCS1 expression was reduced while that of SOCS3 was enhanced, suggesting differential regulation of these regulators by IL-10 to mediate its inhibitory effect. Experiments using various concentrations of exogenously added IL-10 over several time-points further revealed the differential regulation of SOCS 1 and 3 by IL-10 in macrophages. Signal transduction pathway inhibition studies demonstrated that the MAPK pathways including p38, MEK and JNK, particularly the latter are possibly involved in inducing SOCS 1 and 3 by CT and added IL-10, correlating with down-regulation of the cytokines, IL-6 and IL-12p40. Overall, our data helps in understanding the mechanisms of IL-10 regulation of inflammation in CT-infected macrophages by shedding light on the roles of SOCS 1 and 3 in mediating this IL-10 anti-inflammatory effect." @default.
- W4313385608 created "2023-01-06" @default.
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- W4313385608 date "2016-05-01" @default.
- W4313385608 modified "2023-09-25" @default.
- W4313385608 title "Deciphering the Role of Suppressor of Cytokine Signaling (SOCS) 1 and 3 in the IL-10 Regulation of Inflammation Induced by Live <i>Chlamydia trachomatis</i> in mouse macrophages" @default.
- W4313385608 doi "https://doi.org/10.4049/jimmunol.196.supp.146.1" @default.
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