Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385622> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4313385622 endingPage "214.17" @default.
- W4313385622 startingPage "214.17" @default.
- W4313385622 abstract "Abstract Blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4) augments anti-tumor immunity and has shown success in treating patients with metastatic melanoma. Mechanisms of anti-CTLA-4 efficacy have been proposed in animal models, yet the mechanisms in humans remain to be elucidated. Increased frequency of ICOS+ CD4+ T cells has been shown to be a marker of drug bioactivity, but discovery of prognostic indicators and baseline indicators of which patients are most likely to benefit from CTLA-4 blockade remains a priority. PBMCs from 29 metastatic melanoma patients in a multicenter compassionate use trial of anti-CTLA-4 antibody were evaluated using flow cytometry. At baseline and 12 weeks following initiation of treatment, CTLA-4, HLA-DR, ICOS, PD-L1, PD-1, and Ki-67 frequencies were assessed on CD4+ and CD8+ T cells, as well as CD3+CD4+ regulatory T cells. Independent of survival, anti-CTLA-4 treatment significantly increased the frequency of ICOS+ CD4+ T cells, corroborating previous findings. Interestingly, this increase was also observed in ICOS+ Tregs, but not in CD8+ T cells. Increased proliferative Ki67+ CD4+ T cells and Ki67+ Tregs upon CTLA-4 blockade were both associated with prolonged overall survival. Additionally, when the frequency of Ki67+ CD4+ T cells post-treatment was compared to the baseline frequency, patients with a ratio greater than 1.5 had greater overall survival. Increased post-treatment absolute lymphocyte count—a known prognostic biomarker—also correlated with clinical outcome. Our results suggest that anti-CTLA-4 therapy may be mediated by proliferation of CD4+ T cells, and we identify this proliferation as a novel prognostic biomarker in metastatic melanoma patients treated with anti-CTLA-4 antibody." @default.
- W4313385622 created "2023-01-06" @default.
- W4313385622 creator A5001477657 @default.
- W4313385622 creator A5025100380 @default.
- W4313385622 creator A5028400010 @default.
- W4313385622 creator A5029588412 @default.
- W4313385622 creator A5055696402 @default.
- W4313385622 creator A5056390227 @default.
- W4313385622 creator A5082604892 @default.
- W4313385622 creator A5086326514 @default.
- W4313385622 creator A5090540001 @default.
- W4313385622 creator A5090931494 @default.
- W4313385622 date "2016-05-01" @default.
- W4313385622 modified "2023-09-23" @default.
- W4313385622 title "Increased CD4+ T cell proliferation upon treatment correlates with improved overall survival of patients with metastatic melanoma upon anti-CTLA-4 therapy" @default.
- W4313385622 doi "https://doi.org/10.4049/jimmunol.196.supp.214.17" @default.
- W4313385622 hasPublicationYear "2016" @default.
- W4313385622 type Work @default.
- W4313385622 citedByCount "0" @default.
- W4313385622 crossrefType "journal-article" @default.
- W4313385622 hasAuthorship W4313385622A5001477657 @default.
- W4313385622 hasAuthorship W4313385622A5025100380 @default.
- W4313385622 hasAuthorship W4313385622A5028400010 @default.
- W4313385622 hasAuthorship W4313385622A5029588412 @default.
- W4313385622 hasAuthorship W4313385622A5055696402 @default.
- W4313385622 hasAuthorship W4313385622A5056390227 @default.
- W4313385622 hasAuthorship W4313385622A5082604892 @default.
- W4313385622 hasAuthorship W4313385622A5086326514 @default.
- W4313385622 hasAuthorship W4313385622A5090540001 @default.
- W4313385622 hasAuthorship W4313385622A5090931494 @default.
- W4313385622 hasConcept C126322002 @default.
- W4313385622 hasConcept C137061746 @default.
- W4313385622 hasConcept C143998085 @default.
- W4313385622 hasConcept C147483822 @default.
- W4313385622 hasConcept C154317977 @default.
- W4313385622 hasConcept C159654299 @default.
- W4313385622 hasConcept C167672396 @default.
- W4313385622 hasConcept C170493617 @default.
- W4313385622 hasConcept C202751555 @default.
- W4313385622 hasConcept C203014093 @default.
- W4313385622 hasConcept C21705690 @default.
- W4313385622 hasConcept C2776090121 @default.
- W4313385622 hasConcept C2777658100 @default.
- W4313385622 hasConcept C2777701055 @default.
- W4313385622 hasConcept C2778468042 @default.
- W4313385622 hasConcept C2781433595 @default.
- W4313385622 hasConcept C502942594 @default.
- W4313385622 hasConcept C553184892 @default.
- W4313385622 hasConcept C55493867 @default.
- W4313385622 hasConcept C71924100 @default.
- W4313385622 hasConcept C86803240 @default.
- W4313385622 hasConcept C8891405 @default.
- W4313385622 hasConceptScore W4313385622C126322002 @default.
- W4313385622 hasConceptScore W4313385622C137061746 @default.
- W4313385622 hasConceptScore W4313385622C143998085 @default.
- W4313385622 hasConceptScore W4313385622C147483822 @default.
- W4313385622 hasConceptScore W4313385622C154317977 @default.
- W4313385622 hasConceptScore W4313385622C159654299 @default.
- W4313385622 hasConceptScore W4313385622C167672396 @default.
- W4313385622 hasConceptScore W4313385622C170493617 @default.
- W4313385622 hasConceptScore W4313385622C202751555 @default.
- W4313385622 hasConceptScore W4313385622C203014093 @default.
- W4313385622 hasConceptScore W4313385622C21705690 @default.
- W4313385622 hasConceptScore W4313385622C2776090121 @default.
- W4313385622 hasConceptScore W4313385622C2777658100 @default.
- W4313385622 hasConceptScore W4313385622C2777701055 @default.
- W4313385622 hasConceptScore W4313385622C2778468042 @default.
- W4313385622 hasConceptScore W4313385622C2781433595 @default.
- W4313385622 hasConceptScore W4313385622C502942594 @default.
- W4313385622 hasConceptScore W4313385622C553184892 @default.
- W4313385622 hasConceptScore W4313385622C55493867 @default.
- W4313385622 hasConceptScore W4313385622C71924100 @default.
- W4313385622 hasConceptScore W4313385622C86803240 @default.
- W4313385622 hasConceptScore W4313385622C8891405 @default.
- W4313385622 hasIssue "1_Supplement" @default.
- W4313385622 hasLocation W43133856221 @default.
- W4313385622 hasOpenAccess W4313385622 @default.
- W4313385622 hasPrimaryLocation W43133856221 @default.
- W4313385622 hasRelatedWork W1927925961 @default.
- W4313385622 hasRelatedWork W2012184857 @default.
- W4313385622 hasRelatedWork W2046134042 @default.
- W4313385622 hasRelatedWork W2049052745 @default.
- W4313385622 hasRelatedWork W2098033626 @default.
- W4313385622 hasRelatedWork W2139188664 @default.
- W4313385622 hasRelatedWork W2393477958 @default.
- W4313385622 hasRelatedWork W2620342065 @default.
- W4313385622 hasRelatedWork W2972882834 @default.
- W4313385622 hasRelatedWork W4214816481 @default.
- W4313385622 hasVolume "196" @default.
- W4313385622 isParatext "false" @default.
- W4313385622 isRetracted "false" @default.
- W4313385622 workType "article" @default.