Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385669> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313385669 endingPage "187.9" @default.
- W4313385669 startingPage "187.9" @default.
- W4313385669 abstract "Abstract Impaired fibrinolysis in systemic lupus erythematosus (SLE) is a contributing factor in disease complications including hyper-coagulation, tissue ischemia/reperfusion (IR), and increased risk of thrombosis: including stroke and deep vein thrombosis. Aberrant complement activation has been identified as a major factor in tissue injury in SLE. Previous work in the laboratory focused on mechanisms of complement activation in IR induced tissue injury in B6.MRL/lpr mice, an autoimmune prone mouse strain with a propensity to develop lymphadenopathy, glomerulonephritis, and polyarthritis. This work identified a C3-independent mechanism of downstream complement C5a generation contributing to tissue injury. Evidence of interplay between the coagulation and complement pathways was identified. Current work elucidates the mechanism by which the two pathways interact. Using a superior mesenteric artery IR model, we utilized complement and specific extrinsic or intrinsic coagulation pathway inhibitors to evaluate and compare resulting tissue pathology, generation of secondary inflammatory mediators, extent of innate immune activation, and generation of breakdown products involved in regulating feedback regulatory loops after ischemic/reperfusion injury. Inhibition of the extrinsic pathway had a greater impact on downstream complement activation, tissue pathology, vascular integrity, and recruitment of innate immune components versus the inhibition of the extrinsic pathway. Understanding the mechanisms of interplay between the pathways in the autoimmune mouse has significant clinical implications – especially in autoimmune diseases in which inflammation and hypercoagulability are known manifestations." @default.
- W4313385669 created "2023-01-06" @default.
- W4313385669 creator A5018708429 @default.
- W4313385669 creator A5020946421 @default.
- W4313385669 creator A5039745523 @default.
- W4313385669 date "2016-05-01" @default.
- W4313385669 modified "2023-10-16" @default.
- W4313385669 title "Mechanisms of Coagulation-Complement pathway interplay in ischemia/reperfusion induced tissue injury." @default.
- W4313385669 doi "https://doi.org/10.4049/jimmunol.196.supp.187.9" @default.
- W4313385669 hasPublicationYear "2016" @default.
- W4313385669 type Work @default.
- W4313385669 citedByCount "0" @default.
- W4313385669 crossrefType "journal-article" @default.
- W4313385669 hasAuthorship W4313385669A5018708429 @default.
- W4313385669 hasAuthorship W4313385669A5020946421 @default.
- W4313385669 hasAuthorship W4313385669A5039745523 @default.
- W4313385669 hasConcept C111684460 @default.
- W4313385669 hasConcept C126322002 @default.
- W4313385669 hasConcept C136449434 @default.
- W4313385669 hasConcept C171279029 @default.
- W4313385669 hasConcept C186738567 @default.
- W4313385669 hasConcept C189446657 @default.
- W4313385669 hasConcept C203014093 @default.
- W4313385669 hasConcept C2776914184 @default.
- W4313385669 hasConcept C2778382381 @default.
- W4313385669 hasConcept C541997718 @default.
- W4313385669 hasConcept C71318922 @default.
- W4313385669 hasConcept C71924100 @default.
- W4313385669 hasConcept C8891405 @default.
- W4313385669 hasConceptScore W4313385669C111684460 @default.
- W4313385669 hasConceptScore W4313385669C126322002 @default.
- W4313385669 hasConceptScore W4313385669C136449434 @default.
- W4313385669 hasConceptScore W4313385669C171279029 @default.
- W4313385669 hasConceptScore W4313385669C186738567 @default.
- W4313385669 hasConceptScore W4313385669C189446657 @default.
- W4313385669 hasConceptScore W4313385669C203014093 @default.
- W4313385669 hasConceptScore W4313385669C2776914184 @default.
- W4313385669 hasConceptScore W4313385669C2778382381 @default.
- W4313385669 hasConceptScore W4313385669C541997718 @default.
- W4313385669 hasConceptScore W4313385669C71318922 @default.
- W4313385669 hasConceptScore W4313385669C71924100 @default.
- W4313385669 hasConceptScore W4313385669C8891405 @default.
- W4313385669 hasIssue "1_Supplement" @default.
- W4313385669 hasLocation W43133856691 @default.
- W4313385669 hasOpenAccess W4313385669 @default.
- W4313385669 hasPrimaryLocation W43133856691 @default.
- W4313385669 hasRelatedWork W1514874279 @default.
- W4313385669 hasRelatedWork W1959181807 @default.
- W4313385669 hasRelatedWork W1971986054 @default.
- W4313385669 hasRelatedWork W2010705611 @default.
- W4313385669 hasRelatedWork W2018509134 @default.
- W4313385669 hasRelatedWork W2026099298 @default.
- W4313385669 hasRelatedWork W2063594243 @default.
- W4313385669 hasRelatedWork W2083566103 @default.
- W4313385669 hasRelatedWork W2791374135 @default.
- W4313385669 hasRelatedWork W3039546911 @default.
- W4313385669 hasVolume "196" @default.
- W4313385669 isParatext "false" @default.
- W4313385669 isRetracted "false" @default.
- W4313385669 workType "article" @default.