Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385739> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313385739 endingPage "127.2" @default.
- W4313385739 startingPage "127.2" @default.
- W4313385739 abstract "Abstract Systemic lupus erythematosus (SLE) is a chronic multifactorial autoimmune disease; its pathology is mainly attributed to auto-antibodies that cause inflammation and tissue damage. Our group proposed that lipids associated in non-bilayer phospholipid arrangements (NPA) are involved in the development of SLE. BALB/c mice developed a disease very similar to human SLE when they received Mn2+ or drugs chlorpromazine, procainamide (which stabilize NPA in the plasma membrane), or liposomes bearing NPA induced by these drugs or by Mn2+. Recently, we found that the gene expression profile of mice with lupus was different to that found in healthy mice and was similar to patients with SLE: in mice with lupus genes involved in presentation of exogenous antigens, antibody production and TLR4 and NOD2 signaling and some genes encoded for complement proteins were over-expressed, while genes for NK cell recognition and apoptosis were under-expressed. In the present study, we used the mouse immunopathology miScriptTM miRNA PCR Array in order to compare mature microRNA profile between mice with lupus and healthy mice. The results indicated 9 microRNAs deregulated, 4 microRNAs were underexpressed (miR-155, miR-146b, miR-23, miR-let-7d) which can regulate positively transcription of RNAs associated with IL-6, IL-1 and 5 microRNAs were overexpressed (miR-205, miR-200a, miR-18a, miR-207 and miR-574) which can regulate negatively transcription of RNAs associated with apoptosis and T cell response. This results were validated used TaqMan microRNA Assays and were similar to those found in human LES. Then this study highlight the importance of microRNAs in regulate immune process that has implications in the pathogenesis of LES an inflammatory disease." @default.
- W4313385739 created "2023-01-06" @default.
- W4313385739 creator A5008533945 @default.
- W4313385739 creator A5028289314 @default.
- W4313385739 creator A5033799184 @default.
- W4313385739 creator A5034641831 @default.
- W4313385739 creator A5039281456 @default.
- W4313385739 creator A5039460365 @default.
- W4313385739 creator A5041610413 @default.
- W4313385739 creator A5060036184 @default.
- W4313385739 date "2016-05-01" @default.
- W4313385739 modified "2023-09-27" @default.
- W4313385739 title "microRNAs profile expression in a mouse model of lupus triggered by lipids associated in non-bilayer phospholipid arrangements" @default.
- W4313385739 doi "https://doi.org/10.4049/jimmunol.196.supp.127.2" @default.
- W4313385739 hasPublicationYear "2016" @default.
- W4313385739 type Work @default.
- W4313385739 citedByCount "0" @default.
- W4313385739 crossrefType "journal-article" @default.
- W4313385739 hasAuthorship W4313385739A5008533945 @default.
- W4313385739 hasAuthorship W4313385739A5028289314 @default.
- W4313385739 hasAuthorship W4313385739A5033799184 @default.
- W4313385739 hasAuthorship W4313385739A5034641831 @default.
- W4313385739 hasAuthorship W4313385739A5039281456 @default.
- W4313385739 hasAuthorship W4313385739A5039460365 @default.
- W4313385739 hasAuthorship W4313385739A5041610413 @default.
- W4313385739 hasAuthorship W4313385739A5060036184 @default.
- W4313385739 hasConcept C104317684 @default.
- W4313385739 hasConcept C126322002 @default.
- W4313385739 hasConcept C145059251 @default.
- W4313385739 hasConcept C153911025 @default.
- W4313385739 hasConcept C159654299 @default.
- W4313385739 hasConcept C190283241 @default.
- W4313385739 hasConcept C203014093 @default.
- W4313385739 hasConcept C2775915377 @default.
- W4313385739 hasConcept C2776912625 @default.
- W4313385739 hasConcept C2776914184 @default.
- W4313385739 hasConcept C2779134260 @default.
- W4313385739 hasConcept C502942594 @default.
- W4313385739 hasConcept C55493867 @default.
- W4313385739 hasConcept C71924100 @default.
- W4313385739 hasConcept C86803240 @default.
- W4313385739 hasConceptScore W4313385739C104317684 @default.
- W4313385739 hasConceptScore W4313385739C126322002 @default.
- W4313385739 hasConceptScore W4313385739C145059251 @default.
- W4313385739 hasConceptScore W4313385739C153911025 @default.
- W4313385739 hasConceptScore W4313385739C159654299 @default.
- W4313385739 hasConceptScore W4313385739C190283241 @default.
- W4313385739 hasConceptScore W4313385739C203014093 @default.
- W4313385739 hasConceptScore W4313385739C2775915377 @default.
- W4313385739 hasConceptScore W4313385739C2776912625 @default.
- W4313385739 hasConceptScore W4313385739C2776914184 @default.
- W4313385739 hasConceptScore W4313385739C2779134260 @default.
- W4313385739 hasConceptScore W4313385739C502942594 @default.
- W4313385739 hasConceptScore W4313385739C55493867 @default.
- W4313385739 hasConceptScore W4313385739C71924100 @default.
- W4313385739 hasConceptScore W4313385739C86803240 @default.
- W4313385739 hasIssue "1_Supplement" @default.
- W4313385739 hasLocation W43133857391 @default.
- W4313385739 hasOpenAccess W4313385739 @default.
- W4313385739 hasPrimaryLocation W43133857391 @default.
- W4313385739 hasRelatedWork W1968509366 @default.
- W4313385739 hasRelatedWork W2029625233 @default.
- W4313385739 hasRelatedWork W2090212930 @default.
- W4313385739 hasRelatedWork W2279690721 @default.
- W4313385739 hasRelatedWork W2400126894 @default.
- W4313385739 hasRelatedWork W2498483441 @default.
- W4313385739 hasRelatedWork W3042659763 @default.
- W4313385739 hasRelatedWork W4313386619 @default.
- W4313385739 hasRelatedWork W66109366 @default.
- W4313385739 hasRelatedWork W1853547293 @default.
- W4313385739 hasVolume "196" @default.
- W4313385739 isParatext "false" @default.
- W4313385739 isRetracted "false" @default.
- W4313385739 workType "article" @default.