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- W4313385788 abstract "Abstract Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS). HLA-DR4 is an MHC class II gene associated with increased risk for MS. Humanized HLA-DR4-transgenic mice were used to probe T cell specificity and affinity during demyelinating disease progression in response to myelin oligodendrocyte glycoprotein (MOG). Using the micropipette adhesion frequency assay to obtain sensitive, physiologically relevant measurements, only 26% of CNS-infiltrating CD4 T cells are reactive to MOG in symptomatic HLA-DR4-expressing mice. Moreover T cells probed for specificity to a modified MOG peptide containing a citrulline residue in position 101 instead of arginine revealed T cells reactive to MOG alone, citrulline-modified MOG, or to both. Of importance, the citrullinated-MOG peptide does not induce paralytic disease on its own. We believe that these results are the first demonstration of T cell reactivity to citrullinated-MOG epitopes in the context of HLA-DR4 presentation to T cells. We suggest that T cell cross-reactivity to native and citrullinated epitopes of MOG provides a mechanism of disease progression and escape from immune tolerance. Further, reactivity to the citrullinated neoepitope has great implications for use as a potential biomarker of disease therapeutic efficacy since citrullination is the result of a deimination reaction that occurs during prolonged inflammation." @default.
- W4313385788 created "2023-01-06" @default.
- W4313385788 creator A5088909532 @default.
- W4313385788 date "2015-05-01" @default.
- W4313385788 modified "2023-09-26" @default.
- W4313385788 title "CD4 T Cell reactivity to both native and citrullinated-MOG epitopes identified in HLA-DR4 mouse model Of demyelinating disease (BA11P.137)" @default.
- W4313385788 doi "https://doi.org/10.4049/jimmunol.194.supp.184.19" @default.
- W4313385788 hasPublicationYear "2015" @default.
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