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- W4313385906 abstract "Abstract We have investigated whether human CD20 (huCD20)-derived peptides are able to elicit a protective anti-tumor immune response in vivo. Based on in silico prediction and in vitro binding to recombinant MHC molecules (Kb, Db, and I-Ab), we first defined candidate peptides able to bind to various MHC molecules in a restricted manner (8-mers restricted to Kb, 9-mers restricted to Db, 15-mers and 20-mers restricted to I-Ab). Naive C57Bl/6 mice were then immunized s.c. with 7 different mixtures of these peptides in presence of adjuvants (CFA/IFA, Montanide ISA 51VG, CpG) and subsequently challenged with EL4-huCD20 tumor cells. Interestingly, a longer survival could be achieved in mice immunized with 5 of the 7 huCD20-derived peptide mixtures. In addition, MHC-peptide fluorescent pentamers (generated using peptides with the highest capacity of binding to MHC molecules) allowed the detection of anti-CD20 specific CD8+ T cells in one of the groups of immunized mice. Overall, we conclude that it is possible to define huCD20-derived peptides that elicit a T-cell response against EL4-huCD20 tumor cells. We suggest that these peptides could be the targets of the adaptive anti-tumor T cell response triggered by anti-CD20 treatment that we previously reported using a mouse model in which immune competent C57Bl/6 mice were i.v. injected with human CD20+ tumor cells and then treated with an anti-huCD20 mAb (1,2). 1. Abès et al., Blood, 2010 2. Deligne et al., Leukemia, 2014" @default.
- W4313385906 created "2023-01-06" @default.
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- W4313385906 date "2015-05-01" @default.
- W4313385906 modified "2023-10-01" @default.
- W4313385906 title "CD20 peptides elicit a protective anti-tumor immune response in vivo (VAC5P.1126)" @default.
- W4313385906 doi "https://doi.org/10.4049/jimmunol.194.supp.73.11" @default.
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