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- W4313385909 abstract "Abstract Mycobacterium tuberculosis (Mtb) infects one third of the world’s population, and an effective vaccine is desperately needed to curb the spread of disease. We have identified that the CD4+ T cell response is critical in combating Mtb. Using an attenuated version of Mycobacterium smegmatis, IKEPLUS, our lab previously identified the mycobacterial ribosome as a potential target to enhance CD4+ T cell responses to Mtb in mice. To directly assess the CD4+ T cell response mounted against the individual mycobacterial ribosomal proteins, we used an E. coli expression system to express and purify all fifty-seven proteins that make up the Mtb ribosome. This Mtb ribosomal library was then used to identify which proteins of the mycobacterial ribosome elicited a CD4+ T cell response in IKEPLUS infected animals by IFN-γ ELISPOT. When CD4+T cells of infected animals were isolated and restimulated with the Mtb ribosomal protein library, twenty-five of the fifty-seven total proteins elicited significant CD4+ Tcell responses. These ELISPOT results indicate that the Mtb ribosome is a highly immunogenic structure with the ability to stimulate strong T cell responses in mice. Further studies will focus on the use of the mycobacterial ribosome and isolated ribosomal proteins as potential components of vaccination regimens for inducing protective immunity against Mycobacterium tuberculosis." @default.
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- W4313385909 date "2015-05-01" @default.
- W4313385909 modified "2023-09-26" @default.
- W4313385909 title "Assessing the capability of the mycobacterial ribosome to elicit a CD4+ T cell response (APP5P.115)" @default.
- W4313385909 doi "https://doi.org/10.4049/jimmunol.194.supp.183.17" @default.
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