Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385931> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313385931 endingPage "146.8" @default.
- W4313385931 startingPage "146.8" @default.
- W4313385931 abstract "Abstract Mycobacterium avium subspecies paraturberculosis is the causative agent of Johne’s disease, an enteritis infection that affects ruminants.This disease has been studied in deer, but there is little information regarding immunity or disease immunopathology. There is evidence that host genetics contribute to resilience or susceptibility to the disease. This study sought to identify genes in the innate and adaptive immune systems as biomarkers for resilient (R) or susceptible (S) phenotypes in red deer. We have bred over 60 animals from sires with a confirmed R or S phenotype. Animals were bled routinely and monocyte derived macrophages (MDMs) or whole PBMCs were obtained and cultured in vitro. Gene expression was determined using qPCR. The 15 most informative gene targets were chosen from a panel of 60 using GenEx software MDMs showed higher levels of expression of immune genes such as IL1A, TNFA, IL23A and IL12A in S animals, as well as genes not typically associated with the immune system, such as PKLR that exhibit this pattern. Conversely, PBMC samples from these animals exhibit higher levels of expression of immune genes such as IFNY, IL17A and IL2 in R animals. These results have been reproduced in animals bred from different sires over several years. We intend to incorporate these gene markers into diagnostic tests to identify R and S animals at an early age. These genes may also provide deeper insights into immune parameters that determine disease outcome in an animal." @default.
- W4313385931 created "2023-01-06" @default.
- W4313385931 creator A5003234477 @default.
- W4313385931 creator A5032040158 @default.
- W4313385931 creator A5045958977 @default.
- W4313385931 date "2015-05-01" @default.
- W4313385931 modified "2023-09-27" @default.
- W4313385931 title "Genetic markers for resilience and susceptibility to Johne's disease In red deer (<i>Cervus elaphus</i>) (VET1P.1120)" @default.
- W4313385931 doi "https://doi.org/10.4049/jimmunol.194.supp.146.8" @default.
- W4313385931 hasPublicationYear "2015" @default.
- W4313385931 type Work @default.
- W4313385931 citedByCount "0" @default.
- W4313385931 crossrefType "journal-article" @default.
- W4313385931 hasAuthorship W4313385931A5003234477 @default.
- W4313385931 hasAuthorship W4313385931A5032040158 @default.
- W4313385931 hasAuthorship W4313385931A5045958977 @default.
- W4313385931 hasConcept C104317684 @default.
- W4313385931 hasConcept C127716648 @default.
- W4313385931 hasConcept C142724271 @default.
- W4313385931 hasConcept C193419808 @default.
- W4313385931 hasConcept C203014093 @default.
- W4313385931 hasConcept C2777849792 @default.
- W4313385931 hasConcept C2779134260 @default.
- W4313385931 hasConcept C2780015948 @default.
- W4313385931 hasConcept C2780374374 @default.
- W4313385931 hasConcept C523546767 @default.
- W4313385931 hasConcept C54355233 @default.
- W4313385931 hasConcept C71924100 @default.
- W4313385931 hasConcept C86803240 @default.
- W4313385931 hasConcept C8891405 @default.
- W4313385931 hasConceptScore W4313385931C104317684 @default.
- W4313385931 hasConceptScore W4313385931C127716648 @default.
- W4313385931 hasConceptScore W4313385931C142724271 @default.
- W4313385931 hasConceptScore W4313385931C193419808 @default.
- W4313385931 hasConceptScore W4313385931C203014093 @default.
- W4313385931 hasConceptScore W4313385931C2777849792 @default.
- W4313385931 hasConceptScore W4313385931C2779134260 @default.
- W4313385931 hasConceptScore W4313385931C2780015948 @default.
- W4313385931 hasConceptScore W4313385931C2780374374 @default.
- W4313385931 hasConceptScore W4313385931C523546767 @default.
- W4313385931 hasConceptScore W4313385931C54355233 @default.
- W4313385931 hasConceptScore W4313385931C71924100 @default.
- W4313385931 hasConceptScore W4313385931C86803240 @default.
- W4313385931 hasConceptScore W4313385931C8891405 @default.
- W4313385931 hasIssue "1_Supplement" @default.
- W4313385931 hasLocation W43133859311 @default.
- W4313385931 hasOpenAccess W4313385931 @default.
- W4313385931 hasPrimaryLocation W43133859311 @default.
- W4313385931 hasRelatedWork W2030063170 @default.
- W4313385931 hasRelatedWork W2043199614 @default.
- W4313385931 hasRelatedWork W2203142822 @default.
- W4313385931 hasRelatedWork W2211259382 @default.
- W4313385931 hasRelatedWork W2269716023 @default.
- W4313385931 hasRelatedWork W2343194419 @default.
- W4313385931 hasRelatedWork W2395671086 @default.
- W4313385931 hasRelatedWork W2481073502 @default.
- W4313385931 hasRelatedWork W2513035246 @default.
- W4313385931 hasRelatedWork W4297988978 @default.
- W4313385931 hasVolume "194" @default.
- W4313385931 isParatext "false" @default.
- W4313385931 isRetracted "false" @default.
- W4313385931 workType "article" @default.