Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385997> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313385997 endingPage "206.21" @default.
- W4313385997 startingPage "206.21" @default.
- W4313385997 abstract "Abstract Pathogens such as HIV or other viruses exhibit considerable sequence diversity as a strategy to escape the host immune system. However, sequence diversity is not limited to infectious agents. The increasing application of DNA sequencing indicates diversity between individuals (germ line mutations) and within individuals (somatic mutations) for many proteins. Such mutations can be connected to diseases such as cancer or autoimmune disease. The knowledge of antibody reactivities within individuals against self and foreign antigens is important for diagnosis, patient stratification, prevention and treatment of disease. Here we describe the application of high content peptide microarrays presenting thousands of peptides to be assayed with ~1µl serum sample of a donor to asses the reactivity pattern of antibodies towards a number of given antigens under consideration of sequence diversity using HIV as an example. A library of 6564 overlapping peptides represents the immunogenic fraction of the HIV proteome and covers the majority of the available sequences from the LANL global HIV-1 database. This high content library enables the assessment of antibody reactivity within different individuals independent on the serotype of the infecting HIV-viruses as well as the breadth and depth of antibody binding after boosting the immune system by vaccination. This concept can be easily adapted to other pathogens as well as self antigens such as tumor-associated antigens." @default.
- W4313385997 created "2023-01-06" @default.
- W4313385997 creator A5002184305 @default.
- W4313385997 creator A5004127808 @default.
- W4313385997 creator A5035644016 @default.
- W4313385997 creator A5042875555 @default.
- W4313385997 creator A5050386434 @default.
- W4313385997 creator A5054247332 @default.
- W4313385997 creator A5068099941 @default.
- W4313385997 creator A5075692819 @default.
- W4313385997 date "2015-05-01" @default.
- W4313385997 modified "2023-10-16" @default.
- W4313385997 title "Peptide microarrays for coverage of sequence diversity in monitoring the B cell immune response (TECH2P.911)" @default.
- W4313385997 doi "https://doi.org/10.4049/jimmunol.194.supp.206.21" @default.
- W4313385997 hasPublicationYear "2015" @default.
- W4313385997 type Work @default.
- W4313385997 citedByCount "0" @default.
- W4313385997 crossrefType "journal-article" @default.
- W4313385997 hasAuthorship W4313385997A5002184305 @default.
- W4313385997 hasAuthorship W4313385997A5004127808 @default.
- W4313385997 hasAuthorship W4313385997A5035644016 @default.
- W4313385997 hasAuthorship W4313385997A5042875555 @default.
- W4313385997 hasAuthorship W4313385997A5050386434 @default.
- W4313385997 hasAuthorship W4313385997A5054247332 @default.
- W4313385997 hasAuthorship W4313385997A5068099941 @default.
- W4313385997 hasAuthorship W4313385997A5075692819 @default.
- W4313385997 hasConcept C10389963 @default.
- W4313385997 hasConcept C104317684 @default.
- W4313385997 hasConcept C104397665 @default.
- W4313385997 hasConcept C147483822 @default.
- W4313385997 hasConcept C150194340 @default.
- W4313385997 hasConcept C159047783 @default.
- W4313385997 hasConcept C159654299 @default.
- W4313385997 hasConcept C203014093 @default.
- W4313385997 hasConcept C2910703447 @default.
- W4313385997 hasConcept C54355233 @default.
- W4313385997 hasConcept C70721500 @default.
- W4313385997 hasConcept C86803240 @default.
- W4313385997 hasConcept C8891405 @default.
- W4313385997 hasConcept C95371953 @default.
- W4313385997 hasConceptScore W4313385997C10389963 @default.
- W4313385997 hasConceptScore W4313385997C104317684 @default.
- W4313385997 hasConceptScore W4313385997C104397665 @default.
- W4313385997 hasConceptScore W4313385997C147483822 @default.
- W4313385997 hasConceptScore W4313385997C150194340 @default.
- W4313385997 hasConceptScore W4313385997C159047783 @default.
- W4313385997 hasConceptScore W4313385997C159654299 @default.
- W4313385997 hasConceptScore W4313385997C203014093 @default.
- W4313385997 hasConceptScore W4313385997C2910703447 @default.
- W4313385997 hasConceptScore W4313385997C54355233 @default.
- W4313385997 hasConceptScore W4313385997C70721500 @default.
- W4313385997 hasConceptScore W4313385997C86803240 @default.
- W4313385997 hasConceptScore W4313385997C8891405 @default.
- W4313385997 hasConceptScore W4313385997C95371953 @default.
- W4313385997 hasIssue "1_Supplement" @default.
- W4313385997 hasLocation W43133859971 @default.
- W4313385997 hasOpenAccess W4313385997 @default.
- W4313385997 hasPrimaryLocation W43133859971 @default.
- W4313385997 hasRelatedWork W149989437 @default.
- W4313385997 hasRelatedWork W1986989724 @default.
- W4313385997 hasRelatedWork W1988589833 @default.
- W4313385997 hasRelatedWork W1999577806 @default.
- W4313385997 hasRelatedWork W2005886681 @default.
- W4313385997 hasRelatedWork W2015447457 @default.
- W4313385997 hasRelatedWork W2094928744 @default.
- W4313385997 hasRelatedWork W2153762892 @default.
- W4313385997 hasRelatedWork W2172356325 @default.
- W4313385997 hasRelatedWork W2952179329 @default.
- W4313385997 hasVolume "194" @default.
- W4313385997 isParatext "false" @default.
- W4313385997 isRetracted "false" @default.
- W4313385997 workType "article" @default.