Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386000> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4313386000 endingPage "194.8" @default.
- W4313386000 startingPage "194.8" @default.
- W4313386000 abstract "Abstract Group B streptococci (GBS) are one of the leading causes of life-threatening sepsis in neonates. Despite intervention with antibiotic therapy, the incidence of lethality is high among GBS-infected infants. The clinical symptoms of sepsis are related to the host-pathogen interaction and exaggerated proinflammatory cytokine production during the process via pathways dependent on Toll-like receptors (TLRs). Over the last few years, it has become evident that protein kinase D1 (PKD1) plays a significant role in the inflammatory process mediated by TLRs. However, it is currently unknown whether PKD1 is activated, and contributes to proinflammatory responses induced by live or antibiotic-killed GBS. In the present study, we found that both live and antibiotic-killed GBS induce activation of PKD1 that is dependent on the TLR signaling adaptor MyD88 and its downstream kinase IRAK1, but not TRAF6. Inhibition of PKD using a pharmacological inhibitor revealed that PKD1 is indispensable for GBS-mediated expression of various cytokines/chemokines in vitro and in vivo. Furthermore, systemic administration of PKD inhibitor protects D-galactosamine-sensitized mice from shock-mediated death caused by antibiotic-killed GBS. Our findings imply that PKD1 is one of the critical factors that play a regulatory role in GBS-induced proinflammatory reactions, and inhibition of PKD1 activation together with antibiotic treatment in GBS-infected neonates might be an effective way to control GBS diseases." @default.
- W4313386000 created "2023-01-06" @default.
- W4313386000 creator A5008065253 @default.
- W4313386000 creator A5011298805 @default.
- W4313386000 creator A5050113915 @default.
- W4313386000 creator A5064561135 @default.
- W4313386000 creator A5087326524 @default.
- W4313386000 creator A5090322485 @default.
- W4313386000 date "2015-05-01" @default.
- W4313386000 modified "2023-09-26" @default.
- W4313386000 title "Group B streptococci induce proinflammatory responses via a protein kinase D1-dependent pathway (INM7P.351)" @default.
- W4313386000 doi "https://doi.org/10.4049/jimmunol.194.supp.194.8" @default.
- W4313386000 hasPublicationYear "2015" @default.
- W4313386000 type Work @default.
- W4313386000 citedByCount "0" @default.
- W4313386000 crossrefType "journal-article" @default.
- W4313386000 hasAuthorship W4313386000A5008065253 @default.
- W4313386000 hasAuthorship W4313386000A5011298805 @default.
- W4313386000 hasAuthorship W4313386000A5050113915 @default.
- W4313386000 hasAuthorship W4313386000A5064561135 @default.
- W4313386000 hasAuthorship W4313386000A5087326524 @default.
- W4313386000 hasAuthorship W4313386000A5090322485 @default.
- W4313386000 hasConcept C164027704 @default.
- W4313386000 hasConcept C203014093 @default.
- W4313386000 hasConcept C2776914184 @default.
- W4313386000 hasConcept C2778384902 @default.
- W4313386000 hasConcept C71924100 @default.
- W4313386000 hasConcept C86803240 @default.
- W4313386000 hasConcept C89423630 @default.
- W4313386000 hasConceptScore W4313386000C164027704 @default.
- W4313386000 hasConceptScore W4313386000C203014093 @default.
- W4313386000 hasConceptScore W4313386000C2776914184 @default.
- W4313386000 hasConceptScore W4313386000C2778384902 @default.
- W4313386000 hasConceptScore W4313386000C71924100 @default.
- W4313386000 hasConceptScore W4313386000C86803240 @default.
- W4313386000 hasConceptScore W4313386000C89423630 @default.
- W4313386000 hasIssue "1_Supplement" @default.
- W4313386000 hasLocation W43133860001 @default.
- W4313386000 hasOpenAccess W4313386000 @default.
- W4313386000 hasPrimaryLocation W43133860001 @default.
- W4313386000 hasRelatedWork W178181029 @default.
- W4313386000 hasRelatedWork W1964723765 @default.
- W4313386000 hasRelatedWork W1980919939 @default.
- W4313386000 hasRelatedWork W1982338503 @default.
- W4313386000 hasRelatedWork W1992493123 @default.
- W4313386000 hasRelatedWork W2106216921 @default.
- W4313386000 hasRelatedWork W2127503919 @default.
- W4313386000 hasRelatedWork W2152168109 @default.
- W4313386000 hasRelatedWork W2408010109 @default.
- W4313386000 hasRelatedWork W2411508033 @default.
- W4313386000 hasVolume "194" @default.
- W4313386000 isParatext "false" @default.
- W4313386000 isRetracted "false" @default.
- W4313386000 workType "article" @default.