Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386056> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313386056 endingPage "58.3" @default.
- W4313386056 startingPage "58.3" @default.
- W4313386056 abstract "Abstract Interleukin (IL)-25, also known as Interleukin (IL)-17E, belonging to the IL-17 family. Unlike the other members, IL-25 has long been deemed as a pro-inflammatory cytokine favoring Th2--type immune response. Here, we show that expression of IL-25 in skin and subcutaneous tissues were constantly, while increased during allograft rejection. At same time, deficiency of IL-25 aggravates skin allograft rejection in murine models. Further experiments showed deficiency of IL-25 down-regulated the expression of Foxp3 among CD4+ cells and aggravated skin allograft rejections in murine models. While, exogenous IL-25 restored the Foxp3 expression and the function of Tregs in vitro. Adoptively transfer of IL-25 deficient Tregs failed to protect the allograft from rejection, compared to the WT Tregs. Moreover, IL-25 promoted phosphorylation of NFAT2, up-regulated the Foxp3 expression and contributed to the function of Tregs. Our findings indicate that IL-25 can promote the function of Tregs via impeding the interaction of NFAT2 and Foxp3, and prolong skin-graft survival." @default.
- W4313386056 created "2023-01-06" @default.
- W4313386056 creator A5019143244 @default.
- W4313386056 creator A5030199923 @default.
- W4313386056 creator A5064416384 @default.
- W4313386056 creator A5067437670 @default.
- W4313386056 creator A5084803961 @default.
- W4313386056 creator A5085352453 @default.
- W4313386056 date "2015-05-01" @default.
- W4313386056 modified "2023-09-30" @default.
- W4313386056 title "IL-25 promotes the function of CD4+CD25+ T regulatory cells and prolongs skin-graft survival in murine models (IRC5P.620)" @default.
- W4313386056 doi "https://doi.org/10.4049/jimmunol.194.supp.58.3" @default.
- W4313386056 hasPublicationYear "2015" @default.
- W4313386056 type Work @default.
- W4313386056 citedByCount "0" @default.
- W4313386056 crossrefType "journal-article" @default.
- W4313386056 hasAuthorship W4313386056A5019143244 @default.
- W4313386056 hasAuthorship W4313386056A5030199923 @default.
- W4313386056 hasAuthorship W4313386056A5064416384 @default.
- W4313386056 hasAuthorship W4313386056A5067437670 @default.
- W4313386056 hasAuthorship W4313386056A5084803961 @default.
- W4313386056 hasAuthorship W4313386056A5085352453 @default.
- W4313386056 hasConcept C14036430 @default.
- W4313386056 hasConcept C203014093 @default.
- W4313386056 hasConcept C2776090121 @default.
- W4313386056 hasConcept C2778296632 @default.
- W4313386056 hasConcept C2778690821 @default.
- W4313386056 hasConcept C2779727006 @default.
- W4313386056 hasConcept C502942594 @default.
- W4313386056 hasConcept C71924100 @default.
- W4313386056 hasConcept C74172505 @default.
- W4313386056 hasConcept C79484868 @default.
- W4313386056 hasConcept C86803240 @default.
- W4313386056 hasConcept C8891405 @default.
- W4313386056 hasConcept C90375314 @default.
- W4313386056 hasConcept C95444343 @default.
- W4313386056 hasConceptScore W4313386056C14036430 @default.
- W4313386056 hasConceptScore W4313386056C203014093 @default.
- W4313386056 hasConceptScore W4313386056C2776090121 @default.
- W4313386056 hasConceptScore W4313386056C2778296632 @default.
- W4313386056 hasConceptScore W4313386056C2778690821 @default.
- W4313386056 hasConceptScore W4313386056C2779727006 @default.
- W4313386056 hasConceptScore W4313386056C502942594 @default.
- W4313386056 hasConceptScore W4313386056C71924100 @default.
- W4313386056 hasConceptScore W4313386056C74172505 @default.
- W4313386056 hasConceptScore W4313386056C79484868 @default.
- W4313386056 hasConceptScore W4313386056C86803240 @default.
- W4313386056 hasConceptScore W4313386056C8891405 @default.
- W4313386056 hasConceptScore W4313386056C90375314 @default.
- W4313386056 hasConceptScore W4313386056C95444343 @default.
- W4313386056 hasIssue "1_Supplement" @default.
- W4313386056 hasLocation W43133860561 @default.
- W4313386056 hasOpenAccess W4313386056 @default.
- W4313386056 hasPrimaryLocation W43133860561 @default.
- W4313386056 hasRelatedWork W102419399 @default.
- W4313386056 hasRelatedWork W130785812 @default.
- W4313386056 hasRelatedWork W1535737655 @default.
- W4313386056 hasRelatedWork W1978189790 @default.
- W4313386056 hasRelatedWork W2019705985 @default.
- W4313386056 hasRelatedWork W2031181139 @default.
- W4313386056 hasRelatedWork W2163016818 @default.
- W4313386056 hasRelatedWork W3028563194 @default.
- W4313386056 hasRelatedWork W3092937783 @default.
- W4313386056 hasRelatedWork W94147574 @default.
- W4313386056 hasVolume "194" @default.
- W4313386056 isParatext "false" @default.
- W4313386056 isRetracted "false" @default.
- W4313386056 workType "article" @default.