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- W4313386057 abstract "Abstract Preeclampsia affects 3 - 17% of pregnancies worldwide and entails serious consequences for both the mother and the fetus. Increasing evidence suggests that active tolerance of the mother towards the fetus does not suffice for healthy pregnancy but that instead bi-directional maternal-fetal tolerance is required. Thus, fetal immunopathology may play a significant role in the pathogenesis of pregnancy disorders. Nevertheless, the impact of preeclampsia on the fetal immune system is unclear. In this case-control study, we examined the phenotype of innate and adaptive immune cells from cord blood of 3rd trimester babies born to healthy mothers and compared them to cord blood from 3rd trimester babies born to mothers with symptomatic preeclampsia. We observed a decrease of CD56hiCD16- non-activated/regulatory NK cells in relation to CD56loCD16+ activated/effector NK cells results in a shift of the NK population toward activated/effector NK cells. The overall percentage of FoxP3+ Treg was significantly reduced, especially the FoxP3lo populations (Resting Treg and Cytokine Treg). Importantly, this reduction in FoxP3+ Treg affected the ratio of CD8+ effector T cells per FoxP3+ Treg in babies born to preeclamptic mothers. These observations indicate that there are significant fetal immune system derangements during preeclampsia. In how far these alterations are cause or effect of the disease is subject to further study." @default.
- W4313386057 created "2023-01-06" @default.
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- W4313386057 date "2015-05-01" @default.
- W4313386057 modified "2023-09-26" @default.
- W4313386057 title "Preeclampsia is characterized by fetal NK cell activation and a reduction in regulatory T cells (IRC11P.427)" @default.
- W4313386057 doi "https://doi.org/10.4049/jimmunol.194.supp.197.9" @default.
- W4313386057 hasPublicationYear "2015" @default.
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