Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386059> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313386059 endingPage "58.4" @default.
- W4313386059 startingPage "58.4" @default.
- W4313386059 abstract "Abstract Natural Tregs (nTregs) are produced in the thymus by selection to self peptide-MHC (spMHC) complexes. There is abundant data in the literature that suggests nTreg TCRs are higher affinity for self than conventional T cells and respond to spMHC in the periphery. To date, no nTreg ligands have been found, in part, possibly because nTregs may have TCR affinities that fall somewhere between the affinties required for positive and negative selection in the thymus for conventional T cells. This implies that although nTreg TCRs may be higher affinity for self, this affinity may still be lower than a conventional T cell TCR has for it's immunological antigen. To overcome this, we have developed a way to increase the affinity for some nTreg TCRs for pMHC while still mainting peptide specificity. Using these higher affinity nTreg TCRs, we can scan peptide-MHC libraries in order to find peptide mimitopes which may lead us to the actual self-peptides which are able stimulate specific nTregs." @default.
- W4313386059 created "2023-01-06" @default.
- W4313386059 creator A5063117501 @default.
- W4313386059 date "2015-05-01" @default.
- W4313386059 modified "2023-09-27" @default.
- W4313386059 title "Searching for natural Treg peptide-MHC ligands by engineering increased affinity/avidity Treg TCRs. (IRC5P.621)" @default.
- W4313386059 doi "https://doi.org/10.4049/jimmunol.194.supp.58.4" @default.
- W4313386059 hasPublicationYear "2015" @default.
- W4313386059 type Work @default.
- W4313386059 citedByCount "0" @default.
- W4313386059 crossrefType "journal-article" @default.
- W4313386059 hasAuthorship W4313386059A5063117501 @default.
- W4313386059 hasConcept C104317684 @default.
- W4313386059 hasConcept C141231307 @default.
- W4313386059 hasConcept C147483822 @default.
- W4313386059 hasConcept C153911025 @default.
- W4313386059 hasConcept C179223381 @default.
- W4313386059 hasConcept C185592680 @default.
- W4313386059 hasConcept C19317047 @default.
- W4313386059 hasConcept C197695756 @default.
- W4313386059 hasConcept C203014093 @default.
- W4313386059 hasConcept C207936829 @default.
- W4313386059 hasConcept C2776090121 @default.
- W4313386059 hasConcept C2779281246 @default.
- W4313386059 hasConcept C2780283098 @default.
- W4313386059 hasConcept C55493867 @default.
- W4313386059 hasConcept C7386963 @default.
- W4313386059 hasConcept C86803240 @default.
- W4313386059 hasConcept C8891405 @default.
- W4313386059 hasConcept C95444343 @default.
- W4313386059 hasConceptScore W4313386059C104317684 @default.
- W4313386059 hasConceptScore W4313386059C141231307 @default.
- W4313386059 hasConceptScore W4313386059C147483822 @default.
- W4313386059 hasConceptScore W4313386059C153911025 @default.
- W4313386059 hasConceptScore W4313386059C179223381 @default.
- W4313386059 hasConceptScore W4313386059C185592680 @default.
- W4313386059 hasConceptScore W4313386059C19317047 @default.
- W4313386059 hasConceptScore W4313386059C197695756 @default.
- W4313386059 hasConceptScore W4313386059C203014093 @default.
- W4313386059 hasConceptScore W4313386059C207936829 @default.
- W4313386059 hasConceptScore W4313386059C2776090121 @default.
- W4313386059 hasConceptScore W4313386059C2779281246 @default.
- W4313386059 hasConceptScore W4313386059C2780283098 @default.
- W4313386059 hasConceptScore W4313386059C55493867 @default.
- W4313386059 hasConceptScore W4313386059C7386963 @default.
- W4313386059 hasConceptScore W4313386059C86803240 @default.
- W4313386059 hasConceptScore W4313386059C8891405 @default.
- W4313386059 hasConceptScore W4313386059C95444343 @default.
- W4313386059 hasIssue "1_Supplement" @default.
- W4313386059 hasLocation W43133860591 @default.
- W4313386059 hasOpenAccess W4313386059 @default.
- W4313386059 hasPrimaryLocation W43133860591 @default.
- W4313386059 hasRelatedWork W1507791472 @default.
- W4313386059 hasRelatedWork W1875273738 @default.
- W4313386059 hasRelatedWork W1994311739 @default.
- W4313386059 hasRelatedWork W1995925083 @default.
- W4313386059 hasRelatedWork W1997919934 @default.
- W4313386059 hasRelatedWork W1999440367 @default.
- W4313386059 hasRelatedWork W2016467630 @default.
- W4313386059 hasRelatedWork W2040392199 @default.
- W4313386059 hasRelatedWork W2074545819 @default.
- W4313386059 hasRelatedWork W2883395222 @default.
- W4313386059 hasVolume "194" @default.
- W4313386059 isParatext "false" @default.
- W4313386059 isRetracted "false" @default.
- W4313386059 workType "article" @default.