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- W4313386083 abstract "Abstract Notch signaling is essential for T cell lineage commitment and is further required during early phases of thymocyte differentiation. Active Notch signaling during these early stages of T cell development inhibits other lineage potentials, such as B cell and myeloid cell (e.g., dendritic cell) potential. However, the intracellular signaling pathways by which Notch signaling regulates T cell differentiation remain unknown. Here we show that the transcriptional factor c-Myc is controlled by Notch signaling which regulates T cell differentiation. In a well-established in vitro differentiation of T lymphocytes from stem cells, Notch signaling directly controls c-Myc expression. Overexpression of active c-Myc promotes while dominant-negative (dn) c-Myc inhibits early cell differentiation. Moreover, c-Myc expression mediated by Notch signaling modulates survivin, an inhibitor of apoptosis (IAP) protein, which is crucial for T cell development. Overexpression of active c-Myc increases while dn c-Myc reduces survivin expression, which is correlated with T cell differentiation within the in vitro differentiation system. These data identify c-Myc, together with survivin, as regulators of the differentiation of T cells from Notch signaling." @default.
- W4313386083 created "2023-01-06" @default.
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- W4313386083 date "2015-05-01" @default.
- W4313386083 modified "2023-10-16" @default.
- W4313386083 title "Regulation of c-Myc/survivin from notch signaling modulates T cell differentiation (HEM2P.250)" @default.
- W4313386083 doi "https://doi.org/10.4049/jimmunol.194.supp.51.20" @default.
- W4313386083 hasPublicationYear "2015" @default.
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