Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386095> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313386095 endingPage "61.11" @default.
- W4313386095 startingPage "61.11" @default.
- W4313386095 abstract "Abstract Host resistance against influenza A virus infection relies on the efficient collaboration of innate and adaptive immune response. Being a major component of innate immune system, NK cells have been confirmed to limit the replication and spread of influenza virus during early infection. However, their roles in the generation of virus-specific CTLs response still remain exclusive. Consistent with our in vitro study on human NK cells, here we firstly confirmed that murine NK cells could be directly infected with mouse-adaptive influenza A PR8 virus in vivo under both systemic and local infection. However, only systemic infection resulted in severe reduction and dysfunction of spleen NK cells, which was accompanied with the poor antigen-specific killing and IFN-γ secretion rather than the decrease in quantity of CTLs during the acute phase of infection. Importantly, the adoptive transfer of spleen NK cells from mice suffering from local infection rescued the impaired CTLs in systemic influenza virus-infected mice, whereas no similar effects could be observed by using NK cells from healthy mice. Taken together, our results demonstrated that NK cell-mediated help on the generation of functional influenza virus-specific CTLs was infection-dependent and determined by the dose of infection. This study provided some important information for developing novel NK-cell-targeted strategy against severe influenza infection." @default.
- W4313386095 created "2023-01-06" @default.
- W4313386095 creator A5007945942 @default.
- W4313386095 creator A5010744194 @default.
- W4313386095 creator A5018191774 @default.
- W4313386095 creator A5020076697 @default.
- W4313386095 creator A5039895444 @default.
- W4313386095 creator A5046214153 @default.
- W4313386095 creator A5049563242 @default.
- W4313386095 creator A5051364587 @default.
- W4313386095 creator A5052312733 @default.
- W4313386095 creator A5090072454 @default.
- W4313386095 date "2016-05-01" @default.
- W4313386095 modified "2023-09-27" @default.
- W4313386095 title "Systemic infection ruined NK cell-mediated help on influenza virus-specific CTLs" @default.
- W4313386095 doi "https://doi.org/10.4049/jimmunol.196.supp.61.11" @default.
- W4313386095 hasPublicationYear "2016" @default.
- W4313386095 type Work @default.
- W4313386095 citedByCount "0" @default.
- W4313386095 crossrefType "journal-article" @default.
- W4313386095 hasAuthorship W4313386095A5007945942 @default.
- W4313386095 hasAuthorship W4313386095A5010744194 @default.
- W4313386095 hasAuthorship W4313386095A5018191774 @default.
- W4313386095 hasAuthorship W4313386095A5020076697 @default.
- W4313386095 hasAuthorship W4313386095A5039895444 @default.
- W4313386095 hasAuthorship W4313386095A5046214153 @default.
- W4313386095 hasAuthorship W4313386095A5049563242 @default.
- W4313386095 hasAuthorship W4313386095A5051364587 @default.
- W4313386095 hasAuthorship W4313386095A5052312733 @default.
- W4313386095 hasAuthorship W4313386095A5090072454 @default.
- W4313386095 hasConcept C129374314 @default.
- W4313386095 hasConcept C136449434 @default.
- W4313386095 hasConcept C159047783 @default.
- W4313386095 hasConcept C193419808 @default.
- W4313386095 hasConcept C203014093 @default.
- W4313386095 hasConcept C2522874641 @default.
- W4313386095 hasConcept C2776090121 @default.
- W4313386095 hasConcept C2777546802 @default.
- W4313386095 hasConcept C2780931953 @default.
- W4313386095 hasConcept C86803240 @default.
- W4313386095 hasConcept C8891405 @default.
- W4313386095 hasConcept C90375314 @default.
- W4313386095 hasConceptScore W4313386095C129374314 @default.
- W4313386095 hasConceptScore W4313386095C136449434 @default.
- W4313386095 hasConceptScore W4313386095C159047783 @default.
- W4313386095 hasConceptScore W4313386095C193419808 @default.
- W4313386095 hasConceptScore W4313386095C203014093 @default.
- W4313386095 hasConceptScore W4313386095C2522874641 @default.
- W4313386095 hasConceptScore W4313386095C2776090121 @default.
- W4313386095 hasConceptScore W4313386095C2777546802 @default.
- W4313386095 hasConceptScore W4313386095C2780931953 @default.
- W4313386095 hasConceptScore W4313386095C86803240 @default.
- W4313386095 hasConceptScore W4313386095C8891405 @default.
- W4313386095 hasConceptScore W4313386095C90375314 @default.
- W4313386095 hasIssue "1_Supplement" @default.
- W4313386095 hasLocation W43133860951 @default.
- W4313386095 hasOpenAccess W4313386095 @default.
- W4313386095 hasPrimaryLocation W43133860951 @default.
- W4313386095 hasRelatedWork W1524155111 @default.
- W4313386095 hasRelatedWork W1556307916 @default.
- W4313386095 hasRelatedWork W1557621914 @default.
- W4313386095 hasRelatedWork W2103515427 @default.
- W4313386095 hasRelatedWork W2141330728 @default.
- W4313386095 hasRelatedWork W2582591980 @default.
- W4313386095 hasRelatedWork W2946615038 @default.
- W4313386095 hasRelatedWork W3134883772 @default.
- W4313386095 hasRelatedWork W4206425682 @default.
- W4313386095 hasRelatedWork W4315797293 @default.
- W4313386095 hasVolume "196" @default.
- W4313386095 isParatext "false" @default.
- W4313386095 isRetracted "false" @default.
- W4313386095 workType "article" @default.