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- W4313386253 abstract "Abstract Increased remissions in multiple sclerosis (MS) during late pregnancy may result from high levels of sex steroids such as estrogen (E2) and estriol (E3). In fact, treatment with relatively low doses of E2 can protect against clinical and histological signs of MOG-35-55 induced experimental autoimmune encephalomyelitis (EAE) through mechanisms involving PD-1, PD-L1 and B cells. The current study sought to determine more specifically the contribution of PD-L1 and PD-L2 on B cells in E2-mediated protection. Thus, WT, PD-L1 knockout (KO) and PD-L2 KO mice were implanted with E2 pellets prior to EAE induction and the disease course was followed. Unlike PD-L2 KO mice that were fully protected against EAE after E2 treatment, E2-implanted PD-L1 KO mice were fully susceptible to EAE, with increased numbers of proliferating Th1/Th17 cells in the periphery and severe cellular infiltration and active demyelination in the CNS. Moreover, transfer of B cells from MOG-immunized PD-L1 KO or PD-L2 KO donors into E2-preconditioned B cell deficient μMT-/- recipient mice revealed significantly reduced E2-mediated protection against EAE in recipients of PD-L1 KO B cells, but complete protection in recipients of PD-L2 KO B cells. We conclude that PD-1 interaction with PD-L1 but not PD-L2 on B cells is crucial for E2-mediated protection in EAE and that strategies that enhance PD-1/PD-L1 interactions might potentiate E2 treatment effects in EAE and MS." @default.
- W4313386253 created "2023-01-06" @default.
- W4313386253 creator A5049571127 @default.
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- W4313386253 date "2013-05-01" @default.
- W4313386253 modified "2023-09-23" @default.
- W4313386253 title "PD-1 interaction with PD-L1 but not PD-L2 on B cells mediates protective effects of estrogen against EAE (P5176)" @default.
- W4313386253 doi "https://doi.org/10.4049/jimmunol.190.supp.194.5" @default.
- W4313386253 hasPublicationYear "2013" @default.
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