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- W4313386324 abstract "Abstract Interleukin 4 (IL-4) is critical for optimal B cell activation in T-dependent responses; however, the underlying mechanism remains elusive. In the present study, we demonstrate that IL-4-pretreatment markedly up-regulates STAT6-dependent Igα and Igβ protein expression in a translational manner in primary B cells. Elevated Igα and Igβ protein significantly promotes IgM maturation and IgM surface expression as evidenced by isolated overexpression of Igα and Igβ in a B cell line and this increased surface IgM is associated with augmented BCR-initiated ERK phosphorylation. In vivo, Tfh-derived IL-4 is critical for germinal center B cell expansion as shown by significant reduction of germinal center B cells in SRBC-immunized IL-4 receptor alpha deficient mice relative to wild type control mice. We find that IL-4 facilitates BCR-initiated pre-germinal center B cell activation by up-regulating Igα, Igβ, surface IgM expression and BCR-triggered pERK, all of which were reversed by administration of neutralizing anti-IL-4 antibody. In sum, this study elucidates a novel mechanism for crosstalk between the IL-4 receptor and B cell receptor." @default.
- W4313386324 created "2023-01-06" @default.
- W4313386324 creator A5068331769 @default.
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- W4313386324 date "2013-05-01" @default.
- W4313386324 modified "2023-10-16" @default.
- W4313386324 title "IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and amplified BCR-triggered B cell activation in vitro and in vivo (P6230)" @default.
- W4313386324 doi "https://doi.org/10.4049/jimmunol.190.supp.115.11" @default.
- W4313386324 hasPublicationYear "2013" @default.
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