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- W4313386368 abstract "Abstract Oropharyngeal candidiasis (OPC) is an opportunistic infection of the oral cavity caused primarily by Candida albicans. OPC particularly afflicts HIV+ patients with low CD4 counts, suggesting a role for CD4+ T cells in host defense. Experimental models of OPC have strongly suggested that immunity to OPC is IL-17-dependent, and humans with rare genetic defects that result in Th17 deficiency are associated with the development of OPC. However, other sources of IL-17 have been described, particularly in the innate compartment, but the relative contribution of adaptive and innate sources of IL-17 during OPC has not been well articulated. Here, we showed that development of adaptive immune responses in OPC results in a ~1 log decrease in fungal burden, tightly associated with an increased frequency of antigen-specific CD4+IL-17+ (Th17) cells. Importantly, adoptive transfer of Candida-primed Th17 cells into Rag1-/- mice resulted in protection from disease. Surprisingly, however, CD4-/- mice were resistant to OPC, which was linked, at least in part, with compensatory IL-17 production by both CD8+ and double-negative (DN) T cells. The adoptive transfer of CD8+IL-17+ or DN cells into Rag1-/- mice resulted in protection from OPC. Therefore, Th17 cells contribute to C. albicans clearance but their absence can be compensated by alternative sources of IL-17. These findings implicate CD8+IL-17+ and DN cells as vaccine targets in immunocompromised populations." @default.
- W4313386368 created "2023-01-06" @default.
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- W4313386368 date "2013-05-01" @default.
- W4313386368 modified "2023-09-27" @default.
- W4313386368 title "Th17 cells confer long-term adaptive immunity to oropharyngeal candidiasis (P3308)" @default.
- W4313386368 doi "https://doi.org/10.4049/jimmunol.190.supp.134.7" @default.
- W4313386368 hasPublicationYear "2013" @default.
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