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- W4313386401 abstract "Abstract Toll-like receptor 5 (TLR5) has been widely studied in an inflammatory context, but the effect of TLR5 on the adaptive response to bacterial flagellin has received less attention. Here, we demonstrate that TLR5 expression by DCs allows a 1000-fold enhancement of T cell sensitivity to flagellin, and this enhancement did not require expression of NLRC4 or Myd88. The effect of TLR5 on CD4 T cell sensitivity was independent of the adjuvant effect of flagellin and TLR5 ligation did not alter the sensitivity of OVA-specific T cells. In the spleen, the exquisite T cell sensitivity to flagellin was regulated by CD4-CD8α- dendritic cells and was blocked by a monoclonal antibody to TLR5. In mesenteric lymph nodes, flagellin-specific T cell responses are controlled by a population of CD103-CD11b+ DCs. Thus, TLR5 expression by mucosal and systemic DCs regulates the adaptive immune sensitivity to flagellated pathogens." @default.
- W4313386401 created "2023-01-06" @default.
- W4313386401 creator A5028566893 @default.
- W4313386401 creator A5081608169 @default.
- W4313386401 date "2013-05-01" @default.
- W4313386401 modified "2023-09-27" @default.
- W4313386401 title "CD103-CD11b+ mucosal DCs control CD4 T cell responses to bacterial flagellin (P3179)" @default.
- W4313386401 doi "https://doi.org/10.4049/jimmunol.190.supp.171.2" @default.
- W4313386401 hasPublicationYear "2013" @default.
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