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- W4313386427 abstract "Abstract The reconstitution of the T CD8 lymphocyte population in patients subject to hematopoietic cell transplantation (HCT) depends largely of homeostatic peripheral expansion (HPE) of the T CD8 lymphocytes that were not eliminated during the pre-transplant conditioning regimen or the ones that are contained in the transplanted cells. In order to have an efficient HPE, MHC-I molecules, IL-7 and IL-15 are required. Evidences obtained in our lab indicate that the low and/or heterogeneous MHC-I levels of expression correlate with a inefficient reconstitution of T CD8 lymphocytes in patients that received allogeneic HCT. The deficiency in MHC-I expression could be due to a decrease in the expression of the NLRP12 protein, which has been proposed as a positive regulator of classical and non-classical MHC-I molecules expression. Therefore the objective of the following project is to determine the involvement of NALP12 in the MHC-I expression in monocytes from patients subject to HCT. We studied a cohort of 11 patients, 6 of which received autologous transplant and 5 with allogeneic transplant. Most of the patients present normal levels of T CD8 lymphocytes and a homogeneous expression of MHC-I. The patients that received autologous transplantation show a correlation of r=0.56. Our results suggest that NALP12 could act as an enhancer for the expression of the MHC-I molecules and that this expression could be affected in patients subject to allogeneic HPC transplantation." @default.
- W4313386427 created "2023-01-06" @default.
- W4313386427 creator A5087996707 @default.
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- W4313386427 date "2013-05-01" @default.
- W4313386427 modified "2023-10-18" @default.
- W4313386427 title "NLRP12 protein function in the regulation of MHC-I expression in monocytes of patients transplanted with HPCs and their relationship to the reconstitution of CD8 T lymphocytes. (P1333)" @default.
- W4313386427 doi "https://doi.org/10.4049/jimmunol.190.supp.119.21" @default.
- W4313386427 hasPublicationYear "2013" @default.
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