Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386437> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4313386437 endingPage "120.19" @default.
- W4313386437 startingPage "120.19" @default.
- W4313386437 abstract "Abstract Environmentally-induced alterations in the commensal microbiome have been implicated in the increasing prevalence of food allergy. We found that antibiotic treatment of neonatal mice leads to reduced proportions of regulatory T cells(Tregs) in the colonic lamina propria(LP), impaired production of intestinal IgA, and elevated peanut (PN) specific IgE/IgG1 in response to sensitization. Selective colonization of gnotobiotic mice linked the Treg/IgA inducing capacity to a consortium of bacteria within the Clostridia class. Introduction of either a conventional SPF microbiota or a mixture of Clostridia strains to antibiotic-treated mice restored the Treg and IgA compartments and blocked the induction of a food allergic response. Clostridia colonized gnotobiotic mice displayed increased expression of IL-23 and IL-22 in the colonic LP compartment and the induction of anti-microbial REG3β expression in the epithelium. Collectively, these results suggest that the maintenance of oral tolerance to dietary antigens relies on bacterial populations that induce a barrier protective response, which includes activation of the IL-23/IL22 axis and the expansion of intestinal Tregs and IgA secreting B cells. Our findings hold promise for the development of approaches to prevent or treat food allergy based on modulation of the composition of intestinal microbiota." @default.
- W4313386437 created "2023-01-06" @default.
- W4313386437 creator A5012916305 @default.
- W4313386437 creator A5039795688 @default.
- W4313386437 creator A5042231260 @default.
- W4313386437 creator A5048837291 @default.
- W4313386437 creator A5049894538 @default.
- W4313386437 creator A5053569958 @default.
- W4313386437 creator A5062072610 @default.
- W4313386437 creator A5084458782 @default.
- W4313386437 creator A5086096854 @default.
- W4313386437 creator A5088800372 @default.
- W4313386437 date "2013-05-01" @default.
- W4313386437 modified "2023-09-27" @default.
- W4313386437 title "Commensal bacteria induce a barrier protective response to prevent sensitization to food allergens (P6037)" @default.
- W4313386437 doi "https://doi.org/10.4049/jimmunol.190.supp.120.19" @default.
- W4313386437 hasPublicationYear "2013" @default.
- W4313386437 type Work @default.
- W4313386437 citedByCount "0" @default.
- W4313386437 crossrefType "journal-article" @default.
- W4313386437 hasAuthorship W4313386437A5012916305 @default.
- W4313386437 hasAuthorship W4313386437A5039795688 @default.
- W4313386437 hasAuthorship W4313386437A5042231260 @default.
- W4313386437 hasAuthorship W4313386437A5048837291 @default.
- W4313386437 hasAuthorship W4313386437A5049894538 @default.
- W4313386437 hasAuthorship W4313386437A5053569958 @default.
- W4313386437 hasAuthorship W4313386437A5062072610 @default.
- W4313386437 hasAuthorship W4313386437A5084458782 @default.
- W4313386437 hasAuthorship W4313386437A5086096854 @default.
- W4313386437 hasAuthorship W4313386437A5088800372 @default.
- W4313386437 hasConcept C141105273 @default.
- W4313386437 hasConcept C143121216 @default.
- W4313386437 hasConcept C159654299 @default.
- W4313386437 hasConcept C203014093 @default.
- W4313386437 hasConcept C207480886 @default.
- W4313386437 hasConcept C2776027960 @default.
- W4313386437 hasConcept C2776217527 @default.
- W4313386437 hasConcept C2776953665 @default.
- W4313386437 hasConcept C2777310793 @default.
- W4313386437 hasConcept C2778312467 @default.
- W4313386437 hasConcept C523546767 @default.
- W4313386437 hasConcept C529295009 @default.
- W4313386437 hasConcept C54355233 @default.
- W4313386437 hasConcept C60644358 @default.
- W4313386437 hasConcept C86803240 @default.
- W4313386437 hasConcept C8891405 @default.
- W4313386437 hasConcept C89423630 @default.
- W4313386437 hasConceptScore W4313386437C141105273 @default.
- W4313386437 hasConceptScore W4313386437C143121216 @default.
- W4313386437 hasConceptScore W4313386437C159654299 @default.
- W4313386437 hasConceptScore W4313386437C203014093 @default.
- W4313386437 hasConceptScore W4313386437C207480886 @default.
- W4313386437 hasConceptScore W4313386437C2776027960 @default.
- W4313386437 hasConceptScore W4313386437C2776217527 @default.
- W4313386437 hasConceptScore W4313386437C2776953665 @default.
- W4313386437 hasConceptScore W4313386437C2777310793 @default.
- W4313386437 hasConceptScore W4313386437C2778312467 @default.
- W4313386437 hasConceptScore W4313386437C523546767 @default.
- W4313386437 hasConceptScore W4313386437C529295009 @default.
- W4313386437 hasConceptScore W4313386437C54355233 @default.
- W4313386437 hasConceptScore W4313386437C60644358 @default.
- W4313386437 hasConceptScore W4313386437C86803240 @default.
- W4313386437 hasConceptScore W4313386437C8891405 @default.
- W4313386437 hasConceptScore W4313386437C89423630 @default.
- W4313386437 hasIssue "1_Supplement" @default.
- W4313386437 hasLocation W43133864371 @default.
- W4313386437 hasOpenAccess W4313386437 @default.
- W4313386437 hasPrimaryLocation W43133864371 @default.
- W4313386437 hasRelatedWork W2013304482 @default.
- W4313386437 hasRelatedWork W2051520975 @default.
- W4313386437 hasRelatedWork W2119101301 @default.
- W4313386437 hasRelatedWork W2173863257 @default.
- W4313386437 hasRelatedWork W2512759940 @default.
- W4313386437 hasRelatedWork W2591063312 @default.
- W4313386437 hasRelatedWork W2605480469 @default.
- W4313386437 hasRelatedWork W2623840393 @default.
- W4313386437 hasRelatedWork W3113114371 @default.
- W4313386437 hasRelatedWork W4248198575 @default.
- W4313386437 hasVolume "190" @default.
- W4313386437 isParatext "false" @default.
- W4313386437 isRetracted "false" @default.
- W4313386437 workType "article" @default.