Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313386457> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313386457 endingPage "178.1" @default.
- W4313386457 startingPage "178.1" @default.
- W4313386457 abstract "Abstract Vaccines play an integral role in the fight against infectious diseases. Most current vaccines, however, were developed empirically, both in their formulation and schedule. A deeper understanding of the regulatory pathways involved in both adjuvanted vaccines and multi-injection schedules would contribute greatly to the rational design of future vaccines. Here we report a microarray analysis study of a 3 injection vaccination using Neisseria meningitidis PorB as a vaccine adjuvant and an Ova antigen in a murine model. We observe that the kinetics of the response in a number of gene sets is accelerated, with maximal expression after the second vaccination, rather than the third, in the adjuvanted vaccine. We also observe a recruitment of a number of innate inflammatory pathways, with adjuvanted vaccines eliciting more robust gene expression. Main effects and interactions between the antigen and adjuvant were determined, in particular as related and antibody production. In this report we demonstrate that the inclusion of PorB as an adjuvant into the formulation of a vaccine significantly alters the kinetics and nature of the immune response at a deep transcriptional level. This may provide meaningful implications for the rational design of future adjuvanted vaccines." @default.
- W4313386457 created "2023-01-06" @default.
- W4313386457 creator A5019087018 @default.
- W4313386457 creator A5078739510 @default.
- W4313386457 creator A5086960020 @default.
- W4313386457 creator A5090441146 @default.
- W4313386457 date "2013-05-01" @default.
- W4313386457 modified "2023-09-23" @default.
- W4313386457 title "Transcriptome analysis of <i>N. meningitidis</i> PorB as an adjuvant in a multi-injection vaccination schedule (P4494)" @default.
- W4313386457 doi "https://doi.org/10.4049/jimmunol.190.supp.178.1" @default.
- W4313386457 hasPublicationYear "2013" @default.
- W4313386457 type Work @default.
- W4313386457 citedByCount "0" @default.
- W4313386457 crossrefType "journal-article" @default.
- W4313386457 hasAuthorship W4313386457A5019087018 @default.
- W4313386457 hasAuthorship W4313386457A5078739510 @default.
- W4313386457 hasAuthorship W4313386457A5086960020 @default.
- W4313386457 hasAuthorship W4313386457A5090441146 @default.
- W4313386457 hasConcept C104317684 @default.
- W4313386457 hasConcept C147483822 @default.
- W4313386457 hasConcept C150194340 @default.
- W4313386457 hasConcept C159047783 @default.
- W4313386457 hasConcept C162317418 @default.
- W4313386457 hasConcept C186836561 @default.
- W4313386457 hasConcept C203014093 @default.
- W4313386457 hasConcept C22070199 @default.
- W4313386457 hasConcept C2777863537 @default.
- W4313386457 hasConcept C2778458888 @default.
- W4313386457 hasConcept C2780454893 @default.
- W4313386457 hasConcept C2780791431 @default.
- W4313386457 hasConcept C2780801004 @default.
- W4313386457 hasConcept C523546767 @default.
- W4313386457 hasConcept C54355233 @default.
- W4313386457 hasConcept C71924100 @default.
- W4313386457 hasConcept C8415881 @default.
- W4313386457 hasConcept C86803240 @default.
- W4313386457 hasConcept C8891405 @default.
- W4313386457 hasConceptScore W4313386457C104317684 @default.
- W4313386457 hasConceptScore W4313386457C147483822 @default.
- W4313386457 hasConceptScore W4313386457C150194340 @default.
- W4313386457 hasConceptScore W4313386457C159047783 @default.
- W4313386457 hasConceptScore W4313386457C162317418 @default.
- W4313386457 hasConceptScore W4313386457C186836561 @default.
- W4313386457 hasConceptScore W4313386457C203014093 @default.
- W4313386457 hasConceptScore W4313386457C22070199 @default.
- W4313386457 hasConceptScore W4313386457C2777863537 @default.
- W4313386457 hasConceptScore W4313386457C2778458888 @default.
- W4313386457 hasConceptScore W4313386457C2780454893 @default.
- W4313386457 hasConceptScore W4313386457C2780791431 @default.
- W4313386457 hasConceptScore W4313386457C2780801004 @default.
- W4313386457 hasConceptScore W4313386457C523546767 @default.
- W4313386457 hasConceptScore W4313386457C54355233 @default.
- W4313386457 hasConceptScore W4313386457C71924100 @default.
- W4313386457 hasConceptScore W4313386457C8415881 @default.
- W4313386457 hasConceptScore W4313386457C86803240 @default.
- W4313386457 hasConceptScore W4313386457C8891405 @default.
- W4313386457 hasIssue "1_Supplement" @default.
- W4313386457 hasLocation W43133864571 @default.
- W4313386457 hasOpenAccess W4313386457 @default.
- W4313386457 hasPrimaryLocation W43133864571 @default.
- W4313386457 hasRelatedWork W1906602538 @default.
- W4313386457 hasRelatedWork W2048829263 @default.
- W4313386457 hasRelatedWork W2426289498 @default.
- W4313386457 hasRelatedWork W2734403094 @default.
- W4313386457 hasRelatedWork W2906910087 @default.
- W4313386457 hasRelatedWork W2944352009 @default.
- W4313386457 hasRelatedWork W2989996002 @default.
- W4313386457 hasRelatedWork W3132862874 @default.
- W4313386457 hasRelatedWork W3148329899 @default.
- W4313386457 hasRelatedWork W4313386457 @default.
- W4313386457 hasVolume "190" @default.
- W4313386457 isParatext "false" @default.
- W4313386457 isRetracted "false" @default.
- W4313386457 workType "article" @default.