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- W4313386504 abstract "Abstract Following activation with antigen, naïve B cells undergo a robust proliferative expansion and differentiation that results in the production of numerous distinct cell types with different roles in protective immunity. While some of the transcriptional regulators and extrinsic factors directing differentiation are known, these mechanisms cannot account for the heterogeneity of the response. In this study we tracked the response of single naïve B cells and found that individual cells do not differentiate into all of the cell types found within a polyclonal response. Thus, the heterogeneity found within the polyclonal response is in part the result of different naïve B cells differentiating differently. Ongoing work is focused on determining the contributions that B cell receptor affinity and stochastic competition play in differentiation." @default.
- W4313386504 created "2023-01-06" @default.
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- W4313386504 date "2013-05-01" @default.
- W4313386504 modified "2023-09-27" @default.
- W4313386504 title "Analysis of the differentiation of single antigen-specific B cells early in the primary response (P1477)" @default.
- W4313386504 doi "https://doi.org/10.4049/jimmunol.190.supp.174.24" @default.
- W4313386504 hasPublicationYear "2013" @default.
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