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- W4313386523 abstract "Abstract Chemokines primarily mediate lymphocyte migration. Steatohepatitis caused by metabolic syndrome or alcohol is a common cause of liver disease. We investigated the role of CXCL16/CXCR6 in the development of steatohepatitis. Expression of CXCL16 in liver and isolated cells was analysed with rt-PCR and immunohistochemistry. Serum and supernatant concentrations of CXCL16 were measured with ELISA. Expression of CXCR6 was investigated with flow cytometry. Lymphocyte adhesion was assessed using freshly isolated lymphocytes from liver or peripheral blood flowed over a confluent layer of isolated human hepatic sinusoidal endothelium (HSEC). Whole liver expression of CXCL16 was increased in disease with increasing expression with increasing severity of disease. Isolated HSEC, biliary epithelial cells (BEC) and hepatoma cell lines increased expression of CXCL16 and released soluble CXCR6 in response to proinflammatory cytokines, particularly the combination of TNFα and IFNγ. Liver infiltrating lymphocytes and monocytes were enriched for CXCR6 expression compared to peripheral blood. CD3+CD56+ NKT cells and CD56+ NK cells most commonly expressed CXCR6. Inhibition of CXCR6 or CXCL16 inhibited transmigration of lymphocytes across HSEC. Transmigration was increased by incubating lymphocytes with soluble CXCL16. CXCL16 is expressed in diseased liver where it plays a role in the transmigration of lymphocytes across endothelium. This may represent a new therapeutic target in liver disease." @default.
- W4313386523 created "2023-01-06" @default.
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- W4313386523 date "2013-05-01" @default.
- W4313386523 modified "2023-09-29" @default.
- W4313386523 title "CXCR6/CXCL16 in liver disease (P3145)" @default.
- W4313386523 doi "https://doi.org/10.4049/jimmunol.190.supp.43.34" @default.
- W4313386523 hasPublicationYear "2013" @default.
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