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- W4313386536 endingPage "122.1" @default.
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- W4313386536 abstract "Abstract We have recently shown that Neuropilin-1 (Nrp1), a cell surface molecule originally identified for its role in neuronal development and angiogenesis, is involved in several aspects of immune function. Our recent study provided the first evidence for a central role of Nrp1 in the regulation of CD4 T cell immune responses in experimental autoimmune encephalitis (EAE), a neuroinflammatory disorder. Using a tissue specific deletion system, we observed that the lack of Nrp1 in CD4+ T cells results in increased EAE severity. These conditional knockout mice exhibit preferential TH-17 lineage commitment and decreased regulatory T (Treg) cell functionality. Conversely, CD4+ T cells expressing Nrp1 suppress effector T cell proliferation and cytokine production both in vivo and in vitro, independent of Treg cells. In this study, we demonstrate that treatment with rapamycin, an immunosuppressive agent that also causes the expansion of Treg cells and inhibits Th17 cell development, exacerbated EAE in Nrp1-/- mice but had a delayed onset in WT mice. Furthermore, rapamycin treated Nrp1-/- but not WT mice produced more IL-17 and IFN-gamma which are known to be pathogenic in EAE. These findings suggest that Nrp1 may mediate its immunesuppressive effects via the mammalian target of rapamycin (mTOR) signaling." @default.
- W4313386536 created "2023-01-06" @default.
- W4313386536 creator A5085759771 @default.
- W4313386536 date "2013-05-01" @default.
- W4313386536 modified "2023-09-27" @default.
- W4313386536 title "Neuropilin-1 immune regulation is mediated by the mTOR pathway (P1099)" @default.
- W4313386536 doi "https://doi.org/10.4049/jimmunol.190.supp.122.1" @default.
- W4313386536 hasPublicationYear "2013" @default.
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