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- W4313386546 startingPage "138.3" @default.
- W4313386546 abstract "Abstract Toll-like receptor 4 (TLR4) ligation causes multiple immune responses to host, including inflammations, type-I interferon productions and acquired immune responses. There are a variety of ligands against TLR4, and TLR4 senses those impalpable differences with its co-receptor MD-2. Since TLR4 agonist has highly immunomodulatory functions, it would be useful as an immunostimulator when and if we can harness the responses’ balance. Monophosphoryl lipid A (MPL), one of the artificial derivatives, lacks 1- phosphate and is well-known detoxified agonist. Because of its low inflammatory aspect, MPL has been used for a vaccine adjuvant ingredient. Previous studies reveal that MPL-activated TLR4 transduces its signal by p38-dependent and TIR-domain-containing adapter-inducing interferon-β (TRIF)-biased signaling, though the mechanisms how TLR4 discriminates of MPL has been unclear. Here we focused on the phases of ligand coming into TLR4 and found specific requirement of CD14 and Lipopolysaccharide binding protein (LBP). This unique TLR4 activation induced impaired receptor dimerization and subsequent low inflammatory responses. Our data suggested that the modification of TLR4 activation manners changed responses’ balance." @default.
- W4313386546 created "2023-01-06" @default.
- W4313386546 creator A5029096995 @default.
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- W4313386546 date "2013-05-01" @default.
- W4313386546 modified "2023-10-02" @default.
- W4313386546 title "Differential requirements of CD14 and Lipopolysaccharide Binding Protein in Monophosphoryl lipid A-mediated TLR4 activation (P1209)" @default.
- W4313386546 doi "https://doi.org/10.4049/jimmunol.190.supp.138.3" @default.
- W4313386546 hasPublicationYear "2013" @default.
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