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- W4313386625 endingPage "65.2" @default.
- W4313386625 startingPage "65.2" @default.
- W4313386625 abstract "Abstract Double negative T cells (DNT cells) are the main subset in kidney lymphocytes. In peripheral blood represent less than a 5%, but they gradually accumulate in lymph nodes and spleens of deficient FasL mice (gld). The role of these cells in kidney and how they mediate suppression/regulation are unknown. We performed a comprehensive phenotypic and functional analysis of this population in kidney. Hypothesis: DNT cells modulate immune responses in kidney. They have a suppressive function on cytokine production, playing a role in protection cells from injury. Methods: Purified T lymphocytes from mice were analyzed for expressing surface markers and cytokines secretion. B6 wild type, gld mice and ischemic reperfusion injury mice model were used. Surface and intracellular staining were done and analyzed with flow cytometry. Results: There are more DNT cells in the kidney (B6 and gld) than renal draining lymph nodes or inguinal lymph nodes. The percentage decreases in kidney after reperfusion ischemic injury. DNT cells showed an increased expression of activation markers such as CD44/CD69/CD28 compared to CD4+ and CD8+ in kidney. DNT cells exhibit a low secretion of cytokine like IL-17, IL4 or IFN gamma. Conclusion: Our data shows that double negative T cells have the potential to modulate immune responses in kidney. This is promising for better control of kidney injury or autoimmunodiseases." @default.
- W4313386625 created "2023-01-06" @default.
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- W4313386625 date "2013-05-01" @default.
- W4313386625 modified "2023-10-02" @default.
- W4313386625 title "Phenotypic and functional analysis of double negative T cells in kidney. (P1002)" @default.
- W4313386625 doi "https://doi.org/10.4049/jimmunol.190.supp.65.2" @default.
- W4313386625 hasPublicationYear "2013" @default.
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