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- W4313386670 abstract "Abstract Networks of transcription factors (TF) and cytokines are critical for defining the lineage and function of T cell subsets. The transcription factors FoxP3 and Stat5 play key roles in regulatory T cell differentiation and function, while T-bet, Stat1, and Stat4 are important for T helper 1 (Th1) cells. While assessments of differential cytokine-induced STAT activation in FoxP3+ and T-bet+ T cell subsets are valuable, disparate buffer compatibility characteristics create challenges for these analyses. To enable robust, simultaneous analysis of TF expression and phosphorylation in mouse and human samples, a new experimental buffer system was developed. The buffer allowed successful analysis of phospho-signaling responses to several stimuli in T cell subsets defined by surface CD markers and TF. These studies revealed that FoxP3+ and T-bet+ T cell subsets exhibited similar signaling responses to some cytokines, while responding quite differently to others. For instance, FoxP3+ subsets activated Stat5 more robustly in response to IL-2, while FoxP3- T-bet+ T cells activated Stat4 more robustly in response to IFN-a. Interestingly, the small subset of CD4 T cells co-expressing T-bet and FoxP3 shared many signaling responses with FoxP3+ T-bet- CD4 T cells. The simultaneous analysis of surface markers, TF, and individual phosphorylated signaling proteins provides a powerful tool for the comparison of signaling responses in rare cell subsets." @default.
- W4313386670 created "2023-01-06" @default.
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- W4313386670 date "2013-05-01" @default.
- W4313386670 modified "2023-10-16" @default.
- W4313386670 title "Cytokine signaling responses differ between FoxP3+ and T-bet+ T cell subsets in both mouse and human (P1331)" @default.
- W4313386670 doi "https://doi.org/10.4049/jimmunol.190.supp.208.9" @default.
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