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- W4313386788 abstract "Abstract The CD8αβ coreceptor influences CD8 T cell recognition and responses in anti-tumor and -viral immunity. The ancestor to the human and chimpanzee CD8β gene acquired two additional exons absent in the mouse that lead to the expression of multiple isoforms (M1-M4) as a result of alternative splicing. In humans these isoforms differ in their cytoplasmic tails and in their expression pattern. The M-1 isoform is predominant in naïve T cells whereas M-4 is predominant in effector memory T cells. To study functional differences we are co-transducing CD8α, each CD8β isoform, and MHCI restricted NY-ESO-1 specific TCR into human CD4+ T cells and measuring cytokine production after activation. We have found differences in induction of cytokine producing cells such as the MIP-1β chemokine with different isoforms. The M-4 isoform cytoplasmic tail has unique sorting motifs that regulate its cell surface expression and it is modified by phosphorylation after activation. The cytoplasmic tail of M-4 could associate with ubiquitinated substrates in 293T cells and was itself mono-ubiquitinated. The M-4 isoform has unique properties that likely favored its selection in effector memory T cells." @default.
- W4313386788 created "2023-01-06" @default.
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- W4313386788 date "2011-04-01" @default.
- W4313386788 modified "2023-10-18" @default.
- W4313386788 title "Human CD8β isoforms with distinct cytoplasmic tails differ in modulating T cell response and regulated cell surface expression (109.31)" @default.
- W4313386788 doi "https://doi.org/10.4049/jimmunol.186.supp.109.31" @default.
- W4313386788 hasPublicationYear "2011" @default.
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