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- W4313386793 abstract "Abstract Introduction: B cell depletion (BCD) has been utilized to treat relapsing-remitting multiple sclerosis (MS), but it is also not clear whether BCD ameliorates disability progression. We used an anti-mouse CD20 mAb (5D2), and tested its effects in Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TIDD), a viral CNS infection considered the best experimental animal model of disability progression in MS. Methods: SJL mice were injected intraperitoneally with 5D2 15 days before intracerebral infection of TMEV BeAn strain. 5D2 bioactivity was assessed by flow cytometry assay of CD19+ cells in peripheral blood mononuclear cells (PBMC). Mouse disability was measured by Rotarod, and viral load was measured by real-time reverse transcriptase PCR (RT-PCR) for TMEV RNA. Antibody levels were determined in mouse sera and CSF by ELISA, and in CNS tissues by real-time RT-PCR for IgG RNA. Results: Bioactivity of 5D2 was confirmed by nearly absent CD19+ cells in the peripheral blood from animals with persistent BCD. Antibody responses in both CNS and peripheral system were suppressed during 5D2 treatment. Relatively higher viral loads were detected in 5D2-treated mice than in PBS animals, and the viral levels correlated negatively to IgG production in the brain. 5D2 caused marked worsening of the early encephalitis, possibly from deletion of a B cell phenotype which downregulates inflammation." @default.
- W4313386793 created "2023-01-06" @default.
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- W4313386793 date "2011-04-01" @default.
- W4313386793 modified "2023-09-25" @default.
- W4313386793 title "The effect of B-cell depletion in Theiler's viral model of multiple sclerosis (107.17)" @default.
- W4313386793 doi "https://doi.org/10.4049/jimmunol.186.supp.107.17" @default.
- W4313386793 hasPublicationYear "2011" @default.
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