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- W4313387780 abstract "Abstract Foxp3 is critical for regulatory-T cell function. Although alterations in immunity occur with aging, little is known how aging affects the number, phenotypes and function of CD4+ Foxp3+ T cells in humans. Here, we report that CD4+ Foxp3+ T cells are largely CD4+ CD25bright T cells in healthy elderly (age¡Ã65) and young individuals (age¡Â40) and that the two groups have comparable frequencies of CD4+ Foxp3+ T cells. Although CD4+ Foxp3+ T cells mostly have a memory phenotype (CD45RA-) in both groups, the frequency of such cells was higher in the elderly. However, CD4+ Foxp3+ T cells from the two groups similarly express CTLA-4 which has immunosuppressive function as well as receptors (R) for chemokines (CCR4, CCR5, CXCR3 and CCR7) and cytokines (IL-15Ra, IL-2/-15Rb and IL-7Ra) which are involved in T cell trafficking and maintenance, respectively. More importantly, the inhibitory effect of CD4+ CD25bright T cells expressing Foxp3+ on CD4+ CD25− T cells was not different between the two groups as measured by cell proliferation, IFN-g and IL-10 production. Our study indicates that aging does not affect CD4+ T cell immune regulation by CD4+ Foxp3+ T cells and that therapeutic strategies targeting the latter cells can be considered regardless of age." @default.
- W4313387780 created "2023-01-06" @default.
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- W4313387780 date "2007-04-01" @default.
- W4313387780 modified "2023-10-16" @default.
- W4313387780 title "The effect of aging on CD4+ Foxp3+ T cells in humans (85.23)" @default.
- W4313387780 doi "https://doi.org/10.4049/jimmunol.178.supp.85.23" @default.
- W4313387780 hasPublicationYear "2007" @default.
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