Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313388093> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4313388093 abstract "Nicardipine (NC) is an antihypertensive drug indicated for treatment of high blood pressure and angina. It belongs to BCS class-II, having poor solubility and low oral bioavailability. The present work was aimed at developing pyromellitic dianhydride (PMDA) cross-linked β-cyclodextrin (βCD) nanosponges (NS) for improved solubility and drug release. The βCDNS were prepared by the solvent evaporation method in 1:2, 1:4, 1:6 w/w ratio of β-CD: PMDA. The prepared drug loaded β-CDNS were subjected to characterization studies such as DSC, FESEM, FTIR, PXRD and particle size. Characterisation studies confirmed the formation of nanosponges and the entrapment of drug molecules into them. The βCDNS prepared in 1:4 w/w ratio of βCD: PMDA showed the highest increase in solubility and entrapment efficiency, with particle size of 411 nm and −20.9 mV zeta potential. The molecular docking study revealed the formation of stable complexes through interaction of NC and βCD. The nanosponges were formulated into a capsule dosage form by blending the drug-loaded nanosponges with granulated excipients such as talc, aerosol, lactose and starch. The powder blend showed acceptable flow properties. The in vitro dissolution studies of the optimized capsule formulation, performed using USP Type-I apparatus, showed considerably higher drug release compared to pure NC. Thus, PMDA cross-linked βCDNS represents a novel approach to solubility enhancement and an improved dissolution of the selected model drug." @default.
- W4313388093 created "2023-01-06" @default.
- W4313388093 creator A5014431755 @default.
- W4313388093 creator A5029773264 @default.
- W4313388093 creator A5047850479 @default.
- W4313388093 creator A5077423523 @default.
- W4313388093 date "2022-11-01" @default.
- W4313388093 modified "2023-09-30" @default.
- W4313388093 title "β-Cyclodextrin Nanosponges for Oral Drug Delivery of Anti-Hypertensive Drug" @default.
- W4313388093 doi "https://doi.org/10.3390/ecmc2022-13240" @default.
- W4313388093 hasPublicationYear "2022" @default.
- W4313388093 type Work @default.
- W4313388093 citedByCount "0" @default.
- W4313388093 crossrefType "proceedings-article" @default.
- W4313388093 hasAuthorship W4313388093A5014431755 @default.
- W4313388093 hasAuthorship W4313388093A5029773264 @default.
- W4313388093 hasAuthorship W4313388093A5047850479 @default.
- W4313388093 hasAuthorship W4313388093A5077423523 @default.
- W4313388093 hasBestOaLocation W43133880931 @default.
- W4313388093 hasConcept C13965031 @default.
- W4313388093 hasConcept C147789679 @default.
- W4313388093 hasConcept C155574463 @default.
- W4313388093 hasConcept C178790620 @default.
- W4313388093 hasConcept C181389837 @default.
- W4313388093 hasConcept C185592680 @default.
- W4313388093 hasConcept C187530423 @default.
- W4313388093 hasConcept C2778093655 @default.
- W4313388093 hasConcept C2779227376 @default.
- W4313388093 hasConcept C2779251873 @default.
- W4313388093 hasConcept C2779351475 @default.
- W4313388093 hasConcept C2779433975 @default.
- W4313388093 hasConcept C2780035454 @default.
- W4313388093 hasConcept C2780965675 @default.
- W4313388093 hasConcept C2910962261 @default.
- W4313388093 hasConcept C43617362 @default.
- W4313388093 hasConcept C71924100 @default.
- W4313388093 hasConcept C88380143 @default.
- W4313388093 hasConcept C98274493 @default.
- W4313388093 hasConceptScore W4313388093C13965031 @default.
- W4313388093 hasConceptScore W4313388093C147789679 @default.
- W4313388093 hasConceptScore W4313388093C155574463 @default.
- W4313388093 hasConceptScore W4313388093C178790620 @default.
- W4313388093 hasConceptScore W4313388093C181389837 @default.
- W4313388093 hasConceptScore W4313388093C185592680 @default.
- W4313388093 hasConceptScore W4313388093C187530423 @default.
- W4313388093 hasConceptScore W4313388093C2778093655 @default.
- W4313388093 hasConceptScore W4313388093C2779227376 @default.
- W4313388093 hasConceptScore W4313388093C2779251873 @default.
- W4313388093 hasConceptScore W4313388093C2779351475 @default.
- W4313388093 hasConceptScore W4313388093C2779433975 @default.
- W4313388093 hasConceptScore W4313388093C2780035454 @default.
- W4313388093 hasConceptScore W4313388093C2780965675 @default.
- W4313388093 hasConceptScore W4313388093C2910962261 @default.
- W4313388093 hasConceptScore W4313388093C43617362 @default.
- W4313388093 hasConceptScore W4313388093C71924100 @default.
- W4313388093 hasConceptScore W4313388093C88380143 @default.
- W4313388093 hasConceptScore W4313388093C98274493 @default.
- W4313388093 hasLocation W43133880931 @default.
- W4313388093 hasOpenAccess W4313388093 @default.
- W4313388093 hasPrimaryLocation W43133880931 @default.
- W4313388093 hasRelatedWork W1842011178 @default.
- W4313388093 hasRelatedWork W1966703868 @default.
- W4313388093 hasRelatedWork W1990847867 @default.
- W4313388093 hasRelatedWork W2057262473 @default.
- W4313388093 hasRelatedWork W2066133926 @default.
- W4313388093 hasRelatedWork W2086623451 @default.
- W4313388093 hasRelatedWork W2275322305 @default.
- W4313388093 hasRelatedWork W2314339271 @default.
- W4313388093 hasRelatedWork W2910597072 @default.
- W4313388093 hasRelatedWork W875949149 @default.
- W4313388093 isParatext "false" @default.
- W4313388093 isRetracted "false" @default.
- W4313388093 workType "article" @default.