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- W4313388152 abstract "Abstract We previously evaluated the immunogenicity and efficacy of a virus-like replicon particle (VRP) vaccine expressing the SARS CoV S glycoprotein in mice. SARS S VRP were highly immunogenic and conferred protection upon challenge. To extend that work we have evaluated the immune responses induced by SARS S VRP in macaques immunized at 0, 4 and 24 weeks. PBMC were assayed at two week intervals by ELISPOT and ICS. Post prime, both CD4 and CD8 T cells were found that secrete IFN- γ, IL-2 and TNF- α. The percentage of CD4 cells secreting IFN- γ, IL-2 and TNF- α was substantially more than the percentage of CD4 cells secreting IL-4 post prime indicating a Th1 bias. Post boost, the number of CD4 cells secreting all measured cytokines were equivalent indicating that the SARS S VRP induced a balanced Th1/Th2 response after 2 inoculations. By week 8 a measured decline in the percentage of cytokine-secreting CD8 cells was observed. There were no significant differences in the numbers of T cells secreting cytokines with 2 different VRP dosages given as measured by ICS, however a dose response was seen by ELISPOT. Neutralizing antibodies (NAb) to SARS CoV were measured in sera following post prime and boost inoculations. Three of 4 animals in the low dose group had measurable NAb post boost (GMT = 101) whereas all 4 animals in the high dose group had serum NAb after two doses (GMT = 190). These data provide support to further development of a SARS S VRP vaccine. This study was supported by NIH grant #UC1-AI62582" @default.
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- W4313388152 date "2007-04-01" @default.
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- W4313388152 title "Evaluation of the immunogenicity of an alphavirus replicon particle vaccine expressing the SARS-CoV spike (S) glycoprotein in non-human primates (B191)" @default.
- W4313388152 doi "https://doi.org/10.4049/jimmunol.178.supp.b191" @default.
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