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- W4313388214 abstract "Abstract Expression of the MHC genes has been previously shown to be enhanced at the transcriptional or posttranscriptional level following exposure to cytokine IFN-gamma. However, we here reported that IFN-gamma down regulated the constitutive expression of the FcRn that functions to transport IgG across polarized epithelial cells and protect IgG from degradation. Intestinal epithelial cell, endothelial cell, and macrophage-like THP-1 or fresh isolated human monocytes exposure to IFN-gamma resulted in significantly-decreased human FcRn expression, as assessed by real-time PCR and western blot. Chromatin immunoprecipitation and gel mobility shift assays identified that Stat-1 bound to an IFN-g activation site (GAS) in FcRn promoter region. Functional analysis of luciferase reporter gene under the control of FcRn promoter showed that IFN-gamma had no effect on luciferase expression in JAK- and Stat-deficient cell lines. The unresponsive to IFN-gamma repression was rescued by over-expression of JAK or Stat1, revealing that Stat1-Jak signaling pathway was necessary and sufficient to mediate the repression of IFN-gamma. Furthermore, the inhibitory effects of IFN-gamma responsiveness were selectively reversed or blocked by site-directed mutagenesis of a cis-acting GAS element, and by over-expression of the Stat1 inhibitor, PIAS1, or of the dominant –negative Stat-1 Y701F containing a mutation at Tyr-701. IFN-gamma stimulation dampened down bidirectional transport of IgG across polarized Calu-3 lung epithelial monolayer. Taken together, our results indicate that down-regulation of FcRn gene expression by IFN-gamma may involve direct interaction of activated Stat-1 with the general transcriptional machinery that drives constitutive FcRn expression." @default.
- W4313388214 created "2023-01-06" @default.
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- W4313388214 date "2007-04-01" @default.
- W4313388214 modified "2023-09-27" @default.
- W4313388214 title "Transcriptional repression of the MHC-class I-related Fc receptor for IgG by interferon-gamma through activation of signal transducer and activator of transcription (Stat)-1 (B34)" @default.
- W4313388214 doi "https://doi.org/10.4049/jimmunol.178.supp.b34" @default.
- W4313388214 hasPublicationYear "2007" @default.
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