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- W4313388265 abstract "Abstract The role of CD4+ vs. CD8+ T cells in the generation of low dose oral tolerance is still controversial. To address the roles of these cells in the setting of an intact immune system C57BL/6 mice were fed PBS, OVA, or molar equivalents of MHC Class I (SIINFEKL) or MHC Class II (OVA(323–339)) peptides by gastric lavage followed by immunization with OVA in both hind-leg footpads. Mice were sacrificed and cells from the spleen and draining lymph nodes were restimulated in-vitro with OVA. Mice fed OVA or SIINFEKL before OVA immunization displayed significantly reduced cell proliferation and cytokine (IFN-γ and IL-2) production compared to mice fed PBS. In contrast, feeding OVA(323–339) prior to OVA immunization resulted in elevated levels of IFN-γ and IL-2 upon in-vitro restimulation. However, tolerance was achieved if mice were both fed and immunized with OVA(323–339). The induction of cytokine mRNA (IFN-γ, TGFβ and IL-10) in jejunum, ileum, Peyer’s patches and spleen was then assessed 6h after feeding OVA or peptides. IFN-γ and IL-10 were induced in the jejunum and ileum but not PPs with either OVA or peptides but these cytokines were only seen in the spleen after OVA or OVA(323–339) feeding. These results suggest that the stimulation of CD8+ T cells in the intestine following antigen feeding may be a key step in the induction of low dose oral tolerance." @default.
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- W4313388265 date "2007-04-01" @default.
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- W4313388265 title "The Role of CD8+ T cells in the Development of Oral Tolerance (B14)" @default.
- W4313388265 doi "https://doi.org/10.4049/jimmunol.178.supp.b14" @default.
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