Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313388280> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313388280 endingPage "LB26" @default.
- W4313388280 startingPage "LB26" @default.
- W4313388280 abstract "Abstract Human peripheral blood contains two major dendritic cell populations, namely CD11c−CD123+ plasmacytoid DCs (PDCs) and CD11c+CD123− myeloid DCs (MDCs). Here we have compared PDC and MDC activation in response to Gram-positive Streptococcus pyogenes (group A streptococci) and influenza A virus. S. pyogenes stimulation induced the maturation of both DC types as evidenced by enhanced expression of co-stimulatory molecules and production of pro-inflammatory cytokines and chemokines. Furthermore, S. pyogenes-stimulated PDCs and MDCs activated naive CD4+ T cells and enhanced their Th1 type cytokine production. Influenza A virus infection induced rapid PDC activation whereas MDCs were extremely sensitive to influenza A virus-induced cell death. The most significant differences between DC types were seen in the production of IL-10 and IL-12, which were produced only by S. pyogenes-stimulated MDCs. Although S. pyogenes was able to induce PDC activation, only influenza A virus infection resulted in detectable IFN-α production. Our results show that depending on the infecting microbe the functions of PDCs and MDCs may be partially overlapping suggesting a considerable flexibility of the human DC system." @default.
- W4313388280 created "2023-01-06" @default.
- W4313388280 creator A5007995979 @default.
- W4313388280 creator A5054688234 @default.
- W4313388280 date "2007-04-01" @default.
- W4313388280 modified "2023-09-28" @default.
- W4313388280 title "<i>Streptococcus pyogenes</i> activates human plasmacytoid and myeloid dendritic cells (B123)" @default.
- W4313388280 doi "https://doi.org/10.4049/jimmunol.178.supp.b123" @default.
- W4313388280 hasPublicationYear "2007" @default.
- W4313388280 type Work @default.
- W4313388280 citedByCount "0" @default.
- W4313388280 crossrefType "journal-article" @default.
- W4313388280 hasAuthorship W4313388280A5007995979 @default.
- W4313388280 hasAuthorship W4313388280A5054688234 @default.
- W4313388280 hasConcept C104317684 @default.
- W4313388280 hasConcept C127716648 @default.
- W4313388280 hasConcept C13373296 @default.
- W4313388280 hasConcept C159047783 @default.
- W4313388280 hasConcept C203014093 @default.
- W4313388280 hasConcept C2522874641 @default.
- W4313388280 hasConcept C2776051438 @default.
- W4313388280 hasConcept C2778170410 @default.
- W4313388280 hasConcept C2778690821 @default.
- W4313388280 hasConcept C2779282312 @default.
- W4313388280 hasConcept C2779306812 @default.
- W4313388280 hasConcept C2779489039 @default.
- W4313388280 hasConcept C2779919695 @default.
- W4313388280 hasConcept C523546767 @default.
- W4313388280 hasConcept C54355233 @default.
- W4313388280 hasConcept C55493867 @default.
- W4313388280 hasConcept C86803240 @default.
- W4313388280 hasConcept C8891405 @default.
- W4313388280 hasConcept C89423630 @default.
- W4313388280 hasConceptScore W4313388280C104317684 @default.
- W4313388280 hasConceptScore W4313388280C127716648 @default.
- W4313388280 hasConceptScore W4313388280C13373296 @default.
- W4313388280 hasConceptScore W4313388280C159047783 @default.
- W4313388280 hasConceptScore W4313388280C203014093 @default.
- W4313388280 hasConceptScore W4313388280C2522874641 @default.
- W4313388280 hasConceptScore W4313388280C2776051438 @default.
- W4313388280 hasConceptScore W4313388280C2778170410 @default.
- W4313388280 hasConceptScore W4313388280C2778690821 @default.
- W4313388280 hasConceptScore W4313388280C2779282312 @default.
- W4313388280 hasConceptScore W4313388280C2779306812 @default.
- W4313388280 hasConceptScore W4313388280C2779489039 @default.
- W4313388280 hasConceptScore W4313388280C2779919695 @default.
- W4313388280 hasConceptScore W4313388280C523546767 @default.
- W4313388280 hasConceptScore W4313388280C54355233 @default.
- W4313388280 hasConceptScore W4313388280C55493867 @default.
- W4313388280 hasConceptScore W4313388280C86803240 @default.
- W4313388280 hasConceptScore W4313388280C8891405 @default.
- W4313388280 hasConceptScore W4313388280C89423630 @default.
- W4313388280 hasIssue "1_Supplement" @default.
- W4313388280 hasLocation W43133882801 @default.
- W4313388280 hasOpenAccess W4313388280 @default.
- W4313388280 hasPrimaryLocation W43133882801 @default.
- W4313388280 hasRelatedWork W1970396987 @default.
- W4313388280 hasRelatedWork W1982005727 @default.
- W4313388280 hasRelatedWork W1993894494 @default.
- W4313388280 hasRelatedWork W2005666125 @default.
- W4313388280 hasRelatedWork W2012492220 @default.
- W4313388280 hasRelatedWork W2095840099 @default.
- W4313388280 hasRelatedWork W2102181818 @default.
- W4313388280 hasRelatedWork W2169997919 @default.
- W4313388280 hasRelatedWork W3087626241 @default.
- W4313388280 hasRelatedWork W4313388280 @default.
- W4313388280 hasVolume "178" @default.
- W4313388280 isParatext "false" @default.
- W4313388280 isRetracted "false" @default.
- W4313388280 workType "article" @default.