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- W4313388368 abstract "Abstract Previous in vitro, animal-model, and epidemiological studies have indicated that opiates have conditionally variable effects on HIV-1 susceptibility and disease progression. Immunovirological and pharmacological variability are two major factors that seem to dictate whether HIV-1 infection will progress more rapidly or more slowly in HIV-1 infected opiate-exposed subjects. According to previous studies, the immunovirological effect of the opioid drug methadone has not been elucidated yet. In the present study, we analyzed various immunovirological determinants to evaluate the effects of methadone. Human lymphocytes from healthy individuals were isolated and acutely infected with HIV-1 and then assayed to determine how in vitro exposure of methadone affects HIV-1 infectivity and alters the expression of HIV-1 co-receptor (CXCR4) and mu-opioid receptor (MOR) on HIV-infected CD4+ T-cells. Our results showed that in vitro exposure of methadone increases HIV-1 replication by 4-folds. This was also correlated with a significant increase in the expression of HIV-1 co-receptor CXCR4 and mu-opioid receptor on HIV-infected CD4+ T-cells. Interestingly, we also observed a significant increase of CD4+ T-regulatory cells following methadone in vitro exposure. These results provide a new insight on the immunovirological status of methadone-treated HIV-infected patients. Supported by NIH/RCMI Grant # G12-RR03035." @default.
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- W4313388368 date "2007-04-01" @default.
- W4313388368 modified "2023-10-13" @default.
- W4313388368 title "Increased T-regulatory cell number and expression of CXCR4 and mu-opioid receptors on CD4+ T-cells by methadone is associated with enhancement of HIV-1 infectivity (B17)" @default.
- W4313388368 doi "https://doi.org/10.4049/jimmunol.178.supp.b17" @default.
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