Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313388906> ?p ?o ?g. }
- W4313388906 endingPage "21" @default.
- W4313388906 startingPage "21" @default.
- W4313388906 abstract "Cardiovascular disease is a globally prevalent disease with far-reaching medical and socio-economic consequences. Although improvements in treatment pathways and revascularisation therapies have slowed disease progression, contemporary management fails to modulate the underlying atherosclerotic process and sustainably replace damaged arterial tissue. Direct cellular reprogramming is a rapidly evolving and innovative tissue regenerative approach that holds promise to restore functional vasculature and restore blood perfusion. The approach utilises cell plasticity to directly convert somatic cells to another cell fate without a pluripotent stage. In this narrative literature review, we comprehensively analyse and compare direct reprogramming protocols to generate endothelial cells, vascular smooth muscle cells and vascular progenitors. Specifically, we carefully examine the reprogramming factors, their molecular mechanisms, conversion efficacies and therapeutic benefits for each induced vascular cell. Attention is given to the application of these novel approaches with tissue engineered vascular grafts as a therapeutic and disease-modelling platform for cardiovascular diseases. We conclude with a discussion on the ethics of direct reprogramming, its current challenges, and future perspectives." @default.
- W4313388906 created "2023-01-06" @default.
- W4313388906 creator A5046235931 @default.
- W4313388906 creator A5068399979 @default.
- W4313388906 creator A5088623088 @default.
- W4313388906 date "2022-12-30" @default.
- W4313388906 modified "2023-10-11" @default.
- W4313388906 title "Updated Perspectives on Direct Vascular Cellular Reprogramming and Their Potential Applications in Tissue Engineered Vascular Grafts" @default.
- W4313388906 cites W1521262132 @default.
- W4313388906 cites W1793558192 @default.
- W4313388906 cites W1965378998 @default.
- W4313388906 cites W1965577446 @default.
- W4313388906 cites W1971898007 @default.
- W4313388906 cites W1971950783 @default.
- W4313388906 cites W1977962361 @default.
- W4313388906 cites W1979489258 @default.
- W4313388906 cites W1987991415 @default.
- W4313388906 cites W1996499787 @default.
- W4313388906 cites W2000170902 @default.
- W4313388906 cites W2001765398 @default.
- W4313388906 cites W2011747072 @default.
- W4313388906 cites W2027149936 @default.
- W4313388906 cites W2027464335 @default.
- W4313388906 cites W2030414936 @default.
- W4313388906 cites W2036329770 @default.
- W4313388906 cites W2039068212 @default.
- W4313388906 cites W2056401732 @default.
- W4313388906 cites W2108868980 @default.
- W4313388906 cites W2109508244 @default.
- W4313388906 cites W2111301327 @default.
- W4313388906 cites W2115471418 @default.
- W4313388906 cites W2125987139 @default.
- W4313388906 cites W2128876415 @default.
- W4313388906 cites W2129228205 @default.
- W4313388906 cites W2140465881 @default.
- W4313388906 cites W2144907960 @default.
- W4313388906 cites W2154791520 @default.
- W4313388906 cites W2164775384 @default.
- W4313388906 cites W2253553499 @default.
- W4313388906 cites W2269632789 @default.
- W4313388906 cites W2282254547 @default.
- W4313388906 cites W2287379375 @default.
- W4313388906 cites W2289961865 @default.
- W4313388906 cites W2302418890 @default.
- W4313388906 cites W2313035868 @default.
- W4313388906 cites W2321682596 @default.
- W4313388906 cites W2343127218 @default.
- W4313388906 cites W2493685197 @default.
- W4313388906 cites W2519486002 @default.
- W4313388906 cites W2530432288 @default.
- W4313388906 cites W2539051853 @default.
- W4313388906 cites W2550294408 @default.
- W4313388906 cites W2560576333 @default.
- W4313388906 cites W2565065629 @default.
- W4313388906 cites W2565566948 @default.
- W4313388906 cites W2576206875 @default.
- W4313388906 cites W2583014432 @default.
- W4313388906 cites W2584275995 @default.
- W4313388906 cites W2596666705 @default.
- W4313388906 cites W2605105898 @default.
- W4313388906 cites W2625371898 @default.
- W4313388906 cites W2728750935 @default.
- W4313388906 cites W2736112169 @default.
- W4313388906 cites W2737671506 @default.
- W4313388906 cites W2738080018 @default.
- W4313388906 cites W2739174192 @default.
- W4313388906 cites W2765888851 @default.
- W4313388906 cites W2770379207 @default.
- W4313388906 cites W2781033773 @default.
- W4313388906 cites W2789510077 @default.
- W4313388906 cites W2794478094 @default.
- W4313388906 cites W2794944537 @default.
- W4313388906 cites W2802378500 @default.
- W4313388906 cites W2806109373 @default.
- W4313388906 cites W2811512698 @default.
- W4313388906 cites W2818969815 @default.
- W4313388906 cites W2884374545 @default.
- W4313388906 cites W2888661980 @default.
- W4313388906 cites W2894347786 @default.
- W4313388906 cites W2897412005 @default.
- W4313388906 cites W2916936310 @default.
- W4313388906 cites W2934811368 @default.
- W4313388906 cites W2940936711 @default.
- W4313388906 cites W2963009707 @default.
- W4313388906 cites W2978242631 @default.
- W4313388906 cites W2978802860 @default.
- W4313388906 cites W2982335880 @default.
- W4313388906 cites W2989951181 @default.
- W4313388906 cites W3007916633 @default.
- W4313388906 cites W3032965726 @default.
- W4313388906 cites W3057359622 @default.
- W4313388906 cites W3083391949 @default.
- W4313388906 cites W3083915852 @default.
- W4313388906 cites W3090146615 @default.
- W4313388906 cites W3092957613 @default.
- W4313388906 cites W3095880970 @default.
- W4313388906 cites W3103606383 @default.
- W4313388906 cites W3111967899 @default.