Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313388978> ?p ?o ?g. }
- W4313388978 endingPage "33" @default.
- W4313388978 startingPage "33" @default.
- W4313388978 abstract "The inhibitor of human α-N-acetylgalactosaminidase (α-NaGalase) was isolated from a water-ethanol extract of the brown algae Costaria costata. Currently, tumor α-NaGalase is considered to be a therapeutic target in the treatment of cancer. According to NMR spectroscopy and mass spectrometric analysis, it is a high-molecular-weight fraction of phlorethols with a degree of polymerization (DP) equaling 11-23 phloroglucinols (CcPh). It was shown that CcPh is a direct inhibitor of α-NaGalases isolated from HuTu 80 and SK-MEL-28 cells (IC50 0.14 ± 0.008 and 0.12 ± 0.004 mg/mL, respectively) and reduces the activity of this enzyme in HuTu 80 and SK-MEL-28 cells up to 50% at concentrations of 15.2 ± 9.5 and 5.7 ± 1.6 μg/mL, respectively. Molecular docking of the putative DP-15 oligophlorethol (P15OPh) and heptaphlorethol (PHPh) with human α-NaGalase (PDB ID 4DO4) showed that this compound forms a complex and interacts directly with the Asp 156 and Asp 217 catalytic residues of the enzyme in question. Thus, brown algae phlorethol CcPh is an effective marine-based natural inhibitor of the α-NaGalase of cancer cells and, therefore, has high therapeutic potential." @default.
- W4313388978 created "2023-01-06" @default.
- W4313388978 creator A5016240234 @default.
- W4313388978 creator A5028861589 @default.
- W4313388978 creator A5062556231 @default.
- W4313388978 creator A5064378067 @default.
- W4313388978 creator A5064670668 @default.
- W4313388978 creator A5071514419 @default.
- W4313388978 creator A5079951368 @default.
- W4313388978 date "2022-12-30" @default.
- W4313388978 modified "2023-09-27" @default.
- W4313388978 title "Effect of Phlorotannins from Brown Algae Costaria costata on α-N-Acetylgalactosaminidase Produced by Duodenal Adenocarcinoma and Melanoma Cells" @default.
- W4313388978 cites W1505703661 @default.
- W4313388978 cites W1527349222 @default.
- W4313388978 cites W1558168237 @default.
- W4313388978 cites W1775749144 @default.
- W4313388978 cites W1966605240 @default.
- W4313388978 cites W1969347491 @default.
- W4313388978 cites W2001961425 @default.
- W4313388978 cites W2015009767 @default.
- W4313388978 cites W2018289835 @default.
- W4313388978 cites W2027871586 @default.
- W4313388978 cites W2033079614 @default.
- W4313388978 cites W2034792243 @default.
- W4313388978 cites W2034833194 @default.
- W4313388978 cites W2047339257 @default.
- W4313388978 cites W2056592635 @default.
- W4313388978 cites W2073366463 @default.
- W4313388978 cites W2089796181 @default.
- W4313388978 cites W2100837269 @default.
- W4313388978 cites W2105001798 @default.
- W4313388978 cites W2108362004 @default.
- W4313388978 cites W2122559203 @default.
- W4313388978 cites W2128635872 @default.
- W4313388978 cites W2138882475 @default.
- W4313388978 cites W2162463822 @default.
- W4313388978 cites W2172155744 @default.
- W4313388978 cites W2415545400 @default.
- W4313388978 cites W2606950645 @default.
- W4313388978 cites W265414167 @default.
- W4313388978 cites W2758597563 @default.
- W4313388978 cites W2759778644 @default.
- W4313388978 cites W2778544629 @default.
- W4313388978 cites W2791442967 @default.
- W4313388978 cites W2800428123 @default.
- W4313388978 cites W2949598921 @default.
- W4313388978 cites W2950568940 @default.
- W4313388978 cites W2972648971 @default.
- W4313388978 cites W2981249898 @default.
- W4313388978 cites W3043417644 @default.
- W4313388978 cites W3044498359 @default.
- W4313388978 cites W3111966733 @default.
- W4313388978 cites W3113184108 @default.
- W4313388978 cites W3158293422 @default.
- W4313388978 cites W3200531389 @default.
- W4313388978 cites W3217202325 @default.
- W4313388978 cites W4212947310 @default.
- W4313388978 cites W4281659096 @default.
- W4313388978 cites W4293247451 @default.
- W4313388978 cites W4312082264 @default.
- W4313388978 doi "https://doi.org/10.3390/md21010033" @default.
- W4313388978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36662206" @default.
- W4313388978 hasPublicationYear "2022" @default.
- W4313388978 type Work @default.
- W4313388978 citedByCount "1" @default.
- W4313388978 countsByYear W43133889782023 @default.
- W4313388978 crossrefType "journal-article" @default.
- W4313388978 hasAuthorship W4313388978A5016240234 @default.
- W4313388978 hasAuthorship W4313388978A5028861589 @default.
- W4313388978 hasAuthorship W4313388978A5062556231 @default.
- W4313388978 hasAuthorship W4313388978A5064378067 @default.
- W4313388978 hasAuthorship W4313388978A5064670668 @default.
- W4313388978 hasAuthorship W4313388978A5071514419 @default.
- W4313388978 hasAuthorship W4313388978A5079951368 @default.
- W4313388978 hasBestOaLocation W43133889781 @default.
- W4313388978 hasConcept C153911025 @default.
- W4313388978 hasConcept C181199279 @default.
- W4313388978 hasConcept C185592680 @default.
- W4313388978 hasConcept C202751555 @default.
- W4313388978 hasConcept C2777752497 @default.
- W4313388978 hasConcept C522721590 @default.
- W4313388978 hasConcept C55493867 @default.
- W4313388978 hasConcept C559758991 @default.
- W4313388978 hasConcept C59822182 @default.
- W4313388978 hasConcept C65556437 @default.
- W4313388978 hasConcept C71240020 @default.
- W4313388978 hasConcept C86803240 @default.
- W4313388978 hasConceptScore W4313388978C153911025 @default.
- W4313388978 hasConceptScore W4313388978C181199279 @default.
- W4313388978 hasConceptScore W4313388978C185592680 @default.
- W4313388978 hasConceptScore W4313388978C202751555 @default.
- W4313388978 hasConceptScore W4313388978C2777752497 @default.
- W4313388978 hasConceptScore W4313388978C522721590 @default.
- W4313388978 hasConceptScore W4313388978C55493867 @default.
- W4313388978 hasConceptScore W4313388978C559758991 @default.
- W4313388978 hasConceptScore W4313388978C59822182 @default.
- W4313388978 hasConceptScore W4313388978C65556437 @default.
- W4313388978 hasConceptScore W4313388978C71240020 @default.