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- W4313389059 startingPage "1318" @default.
- W4313389059 abstract "Abstract Exposure of ultraviolet B (UVB) radiation is the main factor from the environment to cause skin photoaging. Lactobacillus rhamnosus ATCC 7469, is a probiotic strain with a good track record for enhancing human health. The present study conducted the impacts of heat‐killed L. rhamnosus ATCC 7469 (RL) on photoaging in vitro using mouse skin fibroblast (MSF) cells and human epidermal melanocytes (HEM) exposed to UVB. The results showed that (1) RL‐protected UVB‐induced cytotoxicity relating to absorb UVB and reduce DNA damage. (2) RL exerted the antiwrinkle impact involved in two aspects. Firstly, RL downregulated MMP‐1, 2, 3 expressions associating with MAPK signaling, resulting in the increased the protein expression of COL1A1, further booting type I collagen abundant thereby promoting the antiwrinkle impact in MSF cells. Secondly, RL reduced ROS content, further decreasing oxidative damage relating to Nrf2/Sirt3/SOD2 signaling, thereby promoting the antiwrinkle impact in MSF cells. (3) RL suppressed tyrosinase and TYRP‐2 activity and/or levels associating with PKA/CREB/MITF signaling, thereby promoting antimelanogenesis impact in HEM cells. In conclusion, our findings suggest that RL could reduce photoaging caused by UVB via antiwrinkle and antimelanogenesis properties and may be a potential antiphotoaging beneficial component, which is applied in the cosmetic industry." @default.
- W4313389059 created "2023-01-06" @default.
- W4313389059 creator A5027403857 @default.
- W4313389059 creator A5027410173 @default.
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- W4313389059 creator A5083716282 @default.
- W4313389059 date "2023-01-11" @default.
- W4313389059 modified "2023-10-17" @default.
- W4313389059 title "Heat‐Killed <i>Lactobacillus rhamnosus</i><scp>ATCC</scp> 7469 Improved <scp>UVB‐Induced</scp> Photoaging <i>Via</i><scp>Antiwrinkle</scp> and <scp>Antimelanogenesis</scp> Impacts" @default.
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