Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313389170> ?p ?o ?g. }
- W4313389170 endingPage "287" @default.
- W4313389170 startingPage "287" @default.
- W4313389170 abstract "Renal cell carcinoma (RCC) is among the 15 most common cancers worldwide, with rising incidence. In most cases, this is a silent disease until it reaches advance stages, demanding new effective biomarkers in all domains, from detection to post-therapy monitoring. Circulating tumor cells (CTC) have the potential to provide minimally invasive information to guide assessment of the disease's aggressiveness and therapeutic strategy, representing a special pool of neoplastic cells which bear metastatic potential. In some tumor models, CTCs' enumeration has been associated with prognosis, but there is a largely unexplored potential for clinical applicability encompassing screening, diagnosis, early detection of metastases, prognosis, response to therapy and monitoring. Nonetheless, lack of standardization and high cost hinder the translation into clinical practice. Thus, new methods for collection and analysis (genomic, proteomic, transcriptomic, epigenomic and metabolomic) are needed to ascertain the role of CTC as a RCC biomarker. Herein, we provide a critical overview of the most recently published data on the role and clinical potential of CTCs in RCC, addressing their biology and the molecular characterization of this remarkable set of tumor cells. Furthermore, we highlight the existing and emerging techniques for CTC enrichment and detection, exploring clinical applications in RCC. Notwithstanding the notable progress in recent years, the use of CTCs in a routine clinical scenario of RCC patients requires further research and technological development, enabling multimodal analysis to take advantage of the wealth of information they provide." @default.
- W4313389170 created "2023-01-06" @default.
- W4313389170 creator A5042199157 @default.
- W4313389170 creator A5057879270 @default.
- W4313389170 creator A5081332955 @default.
- W4313389170 date "2022-12-31" @default.
- W4313389170 modified "2023-10-09" @default.
- W4313389170 title "Circulating Tumor Cells as Biomarkers for Renal Cell Carcinoma: Ready for Prime Time?" @default.
- W4313389170 cites W1981704094 @default.
- W4313389170 cites W2044052665 @default.
- W4313389170 cites W2183070954 @default.
- W4313389170 cites W2338878558 @default.
- W4313389170 cites W2493314228 @default.
- W4313389170 cites W2514976539 @default.
- W4313389170 cites W2531076208 @default.
- W4313389170 cites W2546540003 @default.
- W4313389170 cites W2567292624 @default.
- W4313389170 cites W2617612981 @default.
- W4313389170 cites W2756212937 @default.
- W4313389170 cites W2767599153 @default.
- W4313389170 cites W2777032540 @default.
- W4313389170 cites W2777933299 @default.
- W4313389170 cites W2794173038 @default.
- W4313389170 cites W2795929251 @default.
- W4313389170 cites W2797282777 @default.
- W4313389170 cites W2797542577 @default.
- W4313389170 cites W2800957885 @default.
- W4313389170 cites W2802281270 @default.
- W4313389170 cites W2886602577 @default.
- W4313389170 cites W2892325025 @default.
- W4313389170 cites W2896989496 @default.
- W4313389170 cites W2897077865 @default.
- W4313389170 cites W2898235908 @default.
- W4313389170 cites W2906385796 @default.
- W4313389170 cites W2911199336 @default.
- W4313389170 cites W2911426721 @default.
- W4313389170 cites W2936667683 @default.
- W4313389170 cites W2945013480 @default.
- W4313389170 cites W2946321576 @default.
- W4313389170 cites W2948762763 @default.
- W4313389170 cites W2950902222 @default.
- W4313389170 cites W2954338665 @default.
- W4313389170 cites W2969068393 @default.
- W4313389170 cites W2984803041 @default.
- W4313389170 cites W2986219082 @default.
- W4313389170 cites W2993914517 @default.
- W4313389170 cites W2996405476 @default.
- W4313389170 cites W3005802682 @default.
- W4313389170 cites W3007155651 @default.
- W4313389170 cites W3010091979 @default.
- W4313389170 cites W3012887203 @default.
- W4313389170 cites W3013978542 @default.
- W4313389170 cites W3014187485 @default.
- W4313389170 cites W3020883427 @default.
- W4313389170 cites W3021762514 @default.
- W4313389170 cites W3023809986 @default.
- W4313389170 cites W3025451213 @default.
- W4313389170 cites W3029339183 @default.
- W4313389170 cites W3034411409 @default.
- W4313389170 cites W3043140034 @default.
- W4313389170 cites W3046978201 @default.
- W4313389170 cites W3087571665 @default.
- W4313389170 cites W3088287530 @default.
- W4313389170 cites W3092266429 @default.
- W4313389170 cites W3102271544 @default.
- W4313389170 cites W3109290214 @default.
- W4313389170 cites W3109682997 @default.
- W4313389170 cites W3111820059 @default.
- W4313389170 cites W3112191434 @default.
- W4313389170 cites W3125140576 @default.
- W4313389170 cites W3128646645 @default.
- W4313389170 cites W3131604935 @default.
- W4313389170 cites W3135446690 @default.
- W4313389170 cites W3138136237 @default.
- W4313389170 cites W3144719243 @default.
- W4313389170 cites W3155927899 @default.
- W4313389170 cites W3164913081 @default.
- W4313389170 cites W3169995094 @default.
- W4313389170 cites W3176314022 @default.
- W4313389170 cites W3177425858 @default.
- W4313389170 cites W3180649071 @default.
- W4313389170 cites W3182047288 @default.
- W4313389170 cites W3183375819 @default.
- W4313389170 cites W3187029177 @default.
- W4313389170 cites W3187348111 @default.
- W4313389170 cites W3190821406 @default.
- W4313389170 cites W3193502305 @default.
- W4313389170 cites W3200851617 @default.
- W4313389170 cites W3209705610 @default.
- W4313389170 cites W3210819473 @default.
- W4313389170 cites W3210830395 @default.
- W4313389170 cites W3213578305 @default.
- W4313389170 cites W3214885321 @default.
- W4313389170 cites W3216722440 @default.
- W4313389170 cites W3217081290 @default.
- W4313389170 cites W3217222129 @default.
- W4313389170 cites W4205460633 @default.
- W4313389170 cites W4206364433 @default.