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- W4313389601 abstract "Although the prognosis for acute leukemia has greatly improved, treatment of relapsed/refractory acute leukemia (R/R AL) remains challenging. Recently, increasing evidence indicates that the bone marrow microenvironment (BMM) plays a crucial role in leukemogenesis and therapeutic resistance; therefore, BMM-targeted strategies should be a potent protocol for treating R/R AL. The targeting of cancer-associated fibroblasts (CAFs) in solid tumors has received much attention and has achieved some progress, as CAFs might act as an organizer in the tumor microenvironment. Additionally, over the last 10 years, attention has been drawn to the role of CAFs in the BMM. In spite of certain successes in preclinical and clinical studies, the heterogeneity and plasticity of CAFs mean targeting them is a big challenge. Herein, we review the heterogeneity and roles of CAFs in the BMM and highlight the challenges and opportunities associated with acute leukemia therapies that involve the targeting of CAFs." @default.
- W4313389601 created "2023-01-06" @default.
- W4313389601 creator A5008360001 @default.
- W4313389601 creator A5022646640 @default.
- W4313389601 creator A5089229924 @default.
- W4313389601 date "2022-12-19" @default.
- W4313389601 modified "2023-09-30" @default.
- W4313389601 title "Cancer-associated fibroblasts in acute leukemia" @default.
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